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Molecular cytogenetic delineation of 17q translocation breakpoints in neuroblastoma cell lines

Lookup NU author(s): Dr Maria Lastowska, Dr Nicholas Bown, Professor John LunecORCiD, Professor Tom Strachan, Professor Andrew Pearson, Dr Michael Jackson


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It has recently been recognized that unbalanced translocations resulting in the gain of material from 17q are the most common chromosomal changes in neuroblastoma. These rearrangements are associated with established indicators of bad prognosis and poor patient survival. We have used 13 fluorescence in situ hybridization (FISH) probes to map 12 translocation breakpoints on 17q in 10 neuroblastoma cell lines, identifying at least seven different breakpoints, all localized within the proximal half of 17q (268- 369 cR, 53-68 cM). These results suggest that the dosage of a gene, or genes, in 17q22-qter is responsible for the clinical effects of 17q gain, rather than the disruption of a specific gene. This region contains two genes, nm23- H1 and NGFR, already implicated in neuroblastoma biology.

Publication metadata

Author(s): Lastowska, M., Van Roy, N., Bown, N.P., Speleman, F., Lunec, J., Strachan, T., Pearson, A.D.J., Jackson, M.S.

Publication type: Article

Publication status: Published

Journal: Genes Chromosomes and Cancer

Year: 1998

Volume: 23

Issue: 2

Pages: 116-122

Print publication date: 01/10/1998

ISSN (print): 1045-2257

ISSN (electronic): 1098-2264

PubMed id: 9739014