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The effect of cyclosporin A and Tacrolimus on cultured human epithelial cells: The role of TGF-β

Lookup NU author(s): Dr Helen Robertson, Emeritus Professor John Kirby, David Talbot


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Chronic rejection is a major cause of graft dysfunction following solid organ transplantation. This fibroproliferative disease may be promoted by overproduction of the growth factor TGF-β. It is significant that cyclosporine (CyA) has been associated with upregulation of TGF-β by certain epithelial cells. The current study was designed to compare the effects of CyA and Tacrolimus (FK506) on the growth of cultured human epithelial cells.

Publication metadata

Author(s): Mohamed MAS, Walmsley M, Robertson H, Kirby JA, Talbot D

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: XVIIth World Congress of the Transplantation-Society

Year of Conference: 1999

Pages: 1173-1173

ISSN: 0041-1345

Publisher: Elsevier


DOI: 10.1016/S0041-1345(98)01950-2

PubMed id:

Library holdings: Search Newcastle University Library for this item

Series Title: Transplantation Proceedings

ISBN: 18732623