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The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues

Lookup NU author(s): Dr Geoffrey Coxon, Professor Del Besra, Professor David Minnikin

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Abstract

(11R, 12S)-Lactobacillic acid (1) has been prepared either from D- mannitol by asymmetric cyclopropanation or from cis-cyclopropane-1, 2- dimethanol by enzymatic desymmetrisation. The syntheses of (l1S 12R)- lactobacillic acid (2) and (1R, 2S) 1- (3'-methoxycarbonylpropyl)-2- octadecylcyclopropane (26) and related analogues (27 and 28) have also been achieved.

Publication metadata

Author(s): Coxon GD, Knobl S, Roberts E, Baird MS, Al Dulayymi JR, Besra GS, Brennan PJ, Minnikin DE

Publication type: Article

Publication status: Published

Journal: Tetrahedron Letters

Year: 1999

Volume: 40

Issue: 36

Pages: 6689-6692

Print publication date: 03/09/1999

ISSN (print): 0040-4039

ISSN (electronic): 1873-3581

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0040-4039(99)01378-7

DOI: 10.1016/S0040-4039(99)01378-7

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