Browse by author
Lookup NU author(s): Dr Neil Hanley, Dr Stephen Ball, Dr Mark Clement-Jones, Dr Donna Hagan, Professor Tom Strachan, Emerita Professor Susan Lindsay, Professor Steve RobsonORCiD, Dr David Wilson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The transcription factors SF-1 and WT1 play pivotal roles in mammalian gonadal development and sexual differentiation. In human embryos, both SF-1 and WT1 are expressed when the indifferent gonadal ridge first forms at 32 days post-ovulation. As the sex cords develop - providing morphological evidence of testis differentiation - SF-1 localises predominantly to developing Sertoli cells in the sex cords, whereas WT1 retains a broader pattern of expression. Later, SF-1 localises predominantly to steroidogenic Leydig cells, and WT1 localises to the sex cords. In the ovary, SF-1 and WT1 transcripts persist in the gonadal ridge from the earliest developmental stages throughout the critical period of sex determination. These studies, which delineate for the first time the sequential expression profiles of SF-1 and WT1 during human gonadal development, provide a framework for understanding human sex reversal phenotypes associated with their mutations. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Author(s): Hanley NA, Ball SG, Clement-Jones M, Hagan DM, Strachan T, Lindsay S, Robson S, Ostrer H, Parker KL, Wilson DI
Publication type: Article
Publication status: Published
Journal: Mechanisms of Development
Year: 1999
Volume: 87
Issue: 1-2
Pages: 175-180
Print publication date: 01/09/1999
ISSN (print): 0925-4773
ISSN (electronic): 1872-6356
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/S0925-4773(99)00123-9
DOI: 10.1016/S0925-4773(99)00123-9
PubMed id: 10495282
Altmetrics provided by Altmetric