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Lookup NU author(s): Dr Ian Brotherick,
Dr Brian Shenton,
Dr Brian Angus,
Professor Frederick Campbell
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Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 expression were assessed by flow cytometry in disaggregated tumors. Cyclin D3 expression and S-phase fraction were independently related to Duke's stage. In Duke's stage C tumors, a higher proportion of cells expressed cyclin D3 (14.4 vs. 8.8%, mean; p < 0.05 by Mann-Whitney U test) and were in DNA synthesis (S) phase (21.1 vs. 9.7%, mean; p < 0.05 by Mann-Whitney U test). Neoplastic deregulation of cyclin D3 expression may provide a selective growth advantage which is related to stage in human colorectal cancer.
Author(s): Watson DS, Brotherick I, Shenton BK, Wilson RG, Angus B, Varma JS, Campbell FC
Publication type: Article
Publication status: Published
Print publication date: 01/01/1999
ISSN (print): 0030-2414
ISSN (electronic): 1423-0232
Publisher: S. Karger AG
PubMed id: 9885380
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