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Cyclin D3 expression, cell proliferation and pathological stage of human primary colorectal cancer

Lookup NU author(s): Dr Ian Brotherick, Dr Brian Shenton, Dr Brian Angus, Jagnohan Varma, Professor Frederick Campbell

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Abstract

Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 expression were assessed by flow cytometry in disaggregated tumors. Cyclin D3 expression and S-phase fraction were independently related to Duke's stage. In Duke's stage C tumors, a higher proportion of cells expressed cyclin D3 (14.4 vs. 8.8%, mean; p < 0.05 by Mann-Whitney U test) and were in DNA synthesis (S) phase (21.1 vs. 9.7%, mean; p < 0.05 by Mann-Whitney U test). Neoplastic deregulation of cyclin D3 expression may provide a selective growth advantage which is related to stage in human colorectal cancer.

Publication metadata

Author(s): Watson DS, Brotherick I, Shenton BK, Wilson RG, Angus B, Varma JS, Campbell FC

Publication type: Article

Publication status: Published

Journal: Oncology

Year: 1999

Volume: 56

Issue: 1

Pages: 66-72

Print publication date: 01/01/1999

ISSN (print): 0030-2414

ISSN (electronic): 1423-0232

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000011932

DOI: 10.1159/000011932

PubMed id: 9885380

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