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Development of autoimmune hepatitis following liver transplantation for primary biliary cirrhosis

Lookup NU author(s): Professor David Jones, Emeritus Professor Oliver James, Professor Alastair BurtORCiD, Dr Mark Hudson


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Two patients undergoing liver transplantation for classical end-stage primary biliary cirrhosis (PBC) are described, who went on to develop de novo autoimmune hepatitis (AIH) in the transplanted liver. The presentation, in both instances, was with malaise and lethargy. Markedly elevated serum transaminases were found, together with a raised serum IgG and/or globulin fraction and histological features on liver biopsy typical of AIH. Both cases had had changes in their immunosuppressive therapy before the onset of AIH episodes, and both rapidly responded to reinstitution of steroid therapy. The finding, in each case, of a coincidental multiple HLA class I allele match between the recipient and their liver donor suggests that HLA class I- restricted mechanisms may play an important role in the pathogenesis of AIH.

Publication metadata

Author(s): Jones DEJ, James OFW, Portmann B, Burt AD, Williams R, Hudson M

Publication type: Article

Publication status: Published

Journal: Hepatology

Year: 1999

Volume: 30

Issue: 1

Pages: 53-57

Print publication date: 01/07/1999

ISSN (print): 02709139

ISSN (electronic):


DOI: 10.1002/hep.510300103

PubMed id: 10385638


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