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Poly(ADP-ribose) polymerase is found in both the nucleus and cytoplasm of human CNS neurons

Lookup NU author(s): Dr Mark Cookson, Professor Pamela Shaw

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Abstract

There is evidence that inhibitors of poly(ADP-ribose) polymerase (PARP) may be therapeutically useful in neurodegenerative diseases. Using immunocytochemistry, we have investigated the distribution of PARP in the human CNS. Some neuronal groups showed cytoplasmic staining in addition to the expected staining of nuclei. Considerable variation between different neuronal groups was noted: motor neurons in the spinal cord showed greatest cytoplasmic staining, whereas staining was virtually absent in other neurons, notably in the hippocampus. These results indicate that PARP can be associated with sub-cellular components other than the nucleus, and may indicate additional roles for this enzyme.

Publication metadata

Author(s): Cookson MR, Ince PG, Usher PA, Shaw PJ

Publication type: Article

Publication status: Published

Journal: Brain Research

Year: 1999

Volume: 834

Issue: 1-2

Pages: 182-185

Print publication date: 12/07/1999

ISSN (print): 0006-8993

ISSN (electronic): 1872-6240

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/S0006-8993(99)01559-0

DOI: 10.1016/S0006-8993(99)01559-0

PubMed id: 10407112

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