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Low expression of GluR2 AMPA receptor subunit protein by human motor neurons

Lookup NU author(s): Professor Pamela Shaw, Janet Slade, Professor Christopher EggettORCiD


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Disturbance of glutamate neurotransmission may contribute to motor neuron injury in amyotrophic lateral sclerosis. There is evidence that human motor neurons may express a specific profile of glutamate receptors, with low or absent expression of mRNA for the GluR2 AMPA receptor subunit, which has a crucial role in controlling calcium permeability. This study, using an immunocytochemical approach with a GluR2 specific antibody, shows that human upper and lower motor neurons have a very low/absent expression of GluR2 protein, in contrast to many other neuronal groups. Thus, it is likely that human motor neurons express a high proportion of atypical, calcium permeable AMPA receptors which may contribute to selective vulnerability and may allow cell-specific modulation of the actions of glutamate.

Publication metadata

Author(s): Shaw PJ, Williams TL, Slade JY, Eggett CJ, Ince PG

Publication type: Article

Publication status: Published

Journal: NeuroReport

Year: 1999

Volume: 10

Issue: 2

Pages: 261-265

Print publication date: 05/02/1999

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/00001756-199902050-00011

PubMed id: 10203319


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