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Relapsing ischemic encephaloenteropathy and cryoglobulinemia

Lookup NU author(s): Professor Pamela Shaw


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Cryoglobulinemia is a rare cause of encephalopathy. The authors report three patients with strikingly similar clinical features of recurrent encephalopathy accompanied by symptoms of gastrointestinal ischemia. In only one patient was cryoglobulinemia ascertained in life during the final illness. The autopsy examinations all showed diffuse cerebral, enteral, and systemic small vessel lesions immunoreactive for immunoglobulins and typical of mixed essential cryoglobulinemia. This unusual relapsing clinical syndrome is readily misinterpreted as of nonorganic origin despite its potentially fatal prognosis.

Publication metadata

Author(s): Ince PG, Duffey P, Cochrane HR, Lowe J, Shaw PJ

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2000

Volume: 55

Issue: 10

Pages: 1579-1581

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins


PubMed id: 11094122