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Lookup NU author(s): Dr Martin Prince,
Professor David Jones
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Primary biliary cirrhosis (PBC) is a chronic autoimmune disease characterised by cholestatic liver function tests, antimitochondrial antibodies, and abnormal liver histology. Early descriptions of a rare rapidly progressive disease no longer reflect the more indolent progress often seen today. Many patients have significant long term morbidity through symptoms such as fatigue and itch with a minority progressing to liver failure and need for transplantation. The current data on the diagnosis, clinical progression, and treatment of PBC are reviewed.
Author(s): Prince MI, Jones DEJ
Publication type: Review
Publication status: Published
Journal: Postgraduate Medical Journal
ISSN (print): 0032-5473
ISSN (electronic): 1469-0756
PubMed id: 10727561