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Primary biliary cirrhosis: New perspectives in diagnosis and treatment

Lookup NU author(s): Dr Martin Prince, Professor David Jones


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Primary biliary cirrhosis (PBC) is a chronic autoimmune disease characterised by cholestatic liver function tests, antimitochondrial antibodies, and abnormal liver histology. Early descriptions of a rare rapidly progressive disease no longer reflect the more indolent progress often seen today. Many patients have significant long term morbidity through symptoms such as fatigue and itch with a minority progressing to liver failure and need for transplantation. The current data on the diagnosis, clinical progression, and treatment of PBC are reviewed.

Publication metadata

Author(s): Prince MI, Jones DEJ

Publication type: Review

Publication status: Published

Journal: Postgraduate Medical Journal

Year: 2000

Volume: 76

Issue: 894

Pages: 199-206

ISSN (print): 0032-5473

ISSN (electronic): 1469-0756


DOI: 10.1136/pmj.76.894.199

PubMed id: 10727561