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Intragraft Proliferating T Lymphocytes are associated with Moderate Acute Pulmonary Rejection 1

Lookup NU author(s): Emeritus Professor Nick Europe-Finner, Dr Helen Robertson, Professor Anthony De SoyzaORCiD, Emeritus Professor John Kirby


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Acute allograft rejection is characterized by infiltration of the donor organ by host lymphoid cells, predominantly T lymphocytes. However, the site of proliferation and clonal expansion of alloreactive T lymphocytes is not well defined in man. A group of normal transbronchial biopsies (TBB, n=9) from clinically well lung transplant recipients was compared to TBB showing acute rejection (at least grade A2, n=9), using CD3- and Ki67-specific antibodies to double-label proliferating T lymphocytes. Few double-labeled lymphocytes were present in the normal biopsies (range, 0-3 cells). However, five of the rejection biopsies contained significant numbers of proliferating T lymphocytes (range, 19-47; Fisher's exact test; P=0.029). Furthermore, this positive group contained all three cases of grade A3 rejection in the study, as well as a case with persistent grade A2 rejection on follow-up biopsy. These data demonstrate that T lymphocytes do proliferate in transplanted human lungs; such proliferation is associated with more severe rejection.

Publication metadata

Author(s): Milne DS, Moy JV, Corris PA, Robertson H, De Soyza A, Kirby JA, Cunningham AC

Publication type: Article

Publication status: Published

Journal: Transplantation

Year: 2000

Volume: 69

Issue: 9

Pages: 1981-1984

ISSN (print): 0041-1337

ISSN (electronic): 1534-6080

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/00007890-200005150-00045

PubMed id: 10830247


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