Toggle Main Menu Toggle Search

Open Access padlockePrints

Intragraft Proliferating T Lymphocytes are associated with Moderate Acute Pulmonary Rejection 1

Lookup NU author(s): Dr Helen Robertson, Professor Anthony De SoyzaORCiD, Emeritus Professor John Kirby

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Acute allograft rejection is characterized by infiltration of the donor organ by host lymphoid cells, predominantly T lymphocytes. However, the site of proliferation and clonal expansion of alloreactive T lymphocytes is not well defined in man. A group of normal transbronchial biopsies (TBB, n=9) from clinically well lung transplant recipients was compared to TBB showing acute rejection (at least grade A2, n=9), using CD3- and Ki67-specific antibodies to double-label proliferating T lymphocytes. Few double-labeled lymphocytes were present in the normal biopsies (range, 0-3 cells). However, five of the rejection biopsies contained significant numbers of proliferating T lymphocytes (range, 19-47; Fisher's exact test; P=0.029). Furthermore, this positive group contained all three cases of grade A3 rejection in the study, as well as a case with persistent grade A2 rejection on follow-up biopsy. These data demonstrate that T lymphocytes do proliferate in transplanted human lungs; such proliferation is associated with more severe rejection.


Publication metadata

Author(s): Milne DS, Moy JV, Corris PA, Robertson H, De Soyza A, Kirby JA, Cunningham AC

Publication type: Article

Publication status: Published

Journal: Transplantation

Year: 2000

Volume: 69

Issue: 9

Pages: 1981-1984

ISSN (print): 0041-1337

ISSN (electronic): 1534-6080

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/00007890-200005150-00045

DOI: 10.1097/00007890-200005150-00045

PubMed id: 10830247


Altmetrics

Altmetrics provided by Altmetric


Share