Browse by author
Lookup NU author(s): Professor Patrick Chinnery,
Dr David Samuels,
Emeritus Professor Doug Turnbull,
Professor Robert Lightowlers
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The mammalian mitochondrial genome (mtDNA) is a small double-stranded DNA molecule that is exclusively transmitted down the maternal line. Pathogenic mtDNA mutations are usually heteroplasmic, with a mixture of mutant and wild-type mtDNA within the same organism. A woman harbouring one of these mutations transmits a variable amount of mutant mtDNA to each offspring. This can result in a healthy child or an infant with a devastating and fatal neurological disorder. Understanding the biological basis of this uncertainty is one of the principal challenges facing scientists and clinicians in the field of mitochondrial genetics. Copyright (C) 2000 Elsevier Science Ltd.
Author(s): Chinnery PF, Thorburn DR, Samuels DC, White SL, Dahl H-HM, Turnbull DM, Lightowlers RN, Howell N
Publication type: Article
Publication status: Published
Journal: Trends in Genetics
ISSN (print): 0168-9525
ISSN (electronic): 1362-4555
PubMed id: 11074292
Altmetrics provided by Altmetric