Toggle Main Menu Toggle Search

Open Access padlockePrints

Screening of AP endonuclease as a candidate gene for amyotrophic lateral sclerosis (ALS)

Lookup NU author(s): Dr Janine Tomkins, Susan Dempster, Steven Banner, Dr Mark Cookson, Professor Pamela Shaw

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

DNA extracted from CNS tissue of 84 patients was screened by single- stranded conformation polymorphism (SSCP) and heteroduplex analysis for mutations in the apurinic/apyrimidinic endonuclease (APE) gene. One mutation was identified and characterized as a 4bp deletion in the 3'UTR. A rare polymorphism was identified in exon 3 and a common polymorphism in the coding region of exon 5. These results suggest that APE mutations do not account for a large number of ALS cases. (C) 2000 Lippincott Williams and Wilkins.


Publication metadata

Author(s): Tomkins J, Dempster S, Banner SJ, Cookson MR, Shaw PJ

Publication type: Article

Publication status: Published

Journal: NeuroReport

Year: 2000

Volume: 11

Issue: 8

Pages: 1695-1697

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/00001756-200006050-00020

DOI: 10.1097/00001756-200006050-00020

PubMed id: 10852227


Altmetrics

Altmetrics provided by Altmetric


Share