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Long-term follow-up of patients presenting to adult nephrologists with chronic pyelonephritis and 'normal' renal function

Lookup NU author(s): Professor Tim Goodship, Janet Stoddart, Dr Alison Brown, Dr Michael Ward, Dr John Owen, Professor Robert Wilkinson


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We studied the natural history, and therefore prognosis, of patients with chronic pyelonephritis presenting to adult nephrologists with a plasma or serum creatinine <90 mmol/l. From the Newcastle chronic pyelonephritis database, 255 patients with radiologically-proven disease were reviewed. Median follow-up was 95 months (95%Cl 82.3-109.3). Plasma creatinine was ≤90 μmol/l (P(Cr)≤90 group) at presentation in 138. At presentation, hypertension, bilateral disease and proteinuria were less frequent in the P(Cr)≤90 group (hypertension 19% vs. 32%, p<0.05; bilateral disease 25% vs. 70%, p<0.001; proteinuria 18% vs. 60%, p<0.001). With the exception of two patients, the renal prognosis of this group was excellent. Patients over the age of 18 years presenting to adult nephrologists with a diagnosis of chronic pyelonephritis and a creatinine ≤90 μmol/l can be reassured that the chances of developing end-stage renal failure in the future are very small. Most could be referred back to their general practitioner for long-term follow-up.

Publication metadata

Author(s): Ward MK; Owen JP; Wilkinson R; Goodship THJ; Brown AL; Stoddart JT; Martinek V; Geetha D; Kerr DNS

Publication type: Article

Publication status: Published

Journal: QJM - Monthly Journal of the Association of Physicians

Year: 2000

Volume: 93

Issue: 12

Pages: 799-803

Print publication date: 01/01/2000

ISSN (print): 1460-2725

ISSN (electronic): 1460-2393

Publisher: Oxford University Press


DOI: 10.1093/qjmed/93.12.799

PubMed id: 11110586


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