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Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids

Lookup NU author(s): Professor Alastair Hawkins


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(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme. (C) 2000 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Hawkins AR; Parker EJ; Bello CG; Coggins JR; Abell C

Publication type: Article

Publication status: Published

Journal: Bioorganic and Medicinal Chemistry Letters

Year: 2000

Volume: 10

Issue: 3

Pages: 231-234

ISSN (print): 0960-894X

ISSN (electronic): 1464-3405

Publisher: Pergamon


DOI: 10.1016/S0960-894X(99)00660-5

PubMed id: 10698442


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