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Lookup NU author(s): Professor Derek Manas,
Professor Simi Ali,
Emeritus Professor John Kirby,
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To analyse the contribution of cytomegalovirus (CMV) serology to long-term graft survival in cadaveric kidney transplantation, 404 transplants from a single centre were divided into four subgroups with respect to the combination of donor and recipient CMV antibody status. Graft survival was estimated according to Kaplan-Meier for 1, 3, 5 and 7 years post-transplantation. The single-centre results confirm a negative impact of CMV-positive donor organs for initial graft survival in CMV-negative recipients within the first 3 years after transplantation. However, when 5- and 7-year long-term graft survival was studied, Donor +/Recipient - pairs showed a favourable long-term result, whilst D +/R - pairs had surprisingly a poorer outcome. Therefore, the concept of avoiding transplantation in the D +/R + CMV serology group should be ignored whereas attempts could be made to improve the poor long-term outcome of D +/R + pairs or to reduce its size by organ allocation. © Springer-Verlag 2000.
Author(s): Gerstenkorn C, Balupuri S, Mohamed MA, Manas DM, Ali S, Kirby J, Talbot D
Publication type: Article
Publication status: Published
Journal: Transplant International
Print publication date: 01/01/2000
ISSN (print): 0934-0874
ISSN (electronic): 1432-2277
Publisher: Wiley-Blackwell Publishing Ltd.
PubMed id: 11112035
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