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Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI

Lookup NU author(s): Dr Hubb Middelkoop, Dr Emma Burton, Dr Adrian Lloyd, Dr Sean Paling, Dr Robert Barber, Dr Clive Ballard, Professor Ian McKeith, Professor John O'Brien


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Dementia with Lewy bodies (DLB) is associated with occipital changes in blood flow and metabolism, but structural changes in this region have not previously been assessed. The authors performed volumetric MRI measurement of the occipital lobe blind to the diagnosis in 23 subjects with DLB, 25 with AD, and 24 age-matched control subjects. There were no significant differences between groups in occipital lobe volume. The authors conclude gross structural changes in the occipital lobe do not occur in patients with mild to moderate DLB or AD.

Publication metadata

Author(s): McKeith IG; Lloyd AJ; O'Brien JT; Burton EJ; Barber R; Ballard C; Middelkoop HAM; Van Der Flier WM; Paling S

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2001

Volume: 57

Issue: 11

Pages: 2117-2120

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins


PubMed id: 11739838