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Lookup NU author(s): Professor Alexander Burkle,
Dr Marie-Laure Muiras,
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Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span. © 2002 Published by Elsevier Science Inc.
Author(s): Burkle A, Beneke S, Brabeck C, Leake A, Meyer R, Muiras M-L, Pfeiffer R
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: 2nd Euroconference on Biological Ageing
Year of Conference: 2002
Publisher: Experimental Gerontology, Elsevier
PubMed id: 12470832
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