Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity

Burkle, A; Beneke, S; Brabeck, C; Leake, A; Meyer, R; Muiras, M-L; Pfeiffer, R

doi:10.1016/S0531-5565(02)00144-4

Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity

Lookup NU author(s): Professor Alexander Burkle, Alan Leake, Dr Marie-Laure Muiras, Ragen Pfeiffer

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Abstract

Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span. © 2002 Published by Elsevier Science Inc.