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Effect of an acute fast on energy compensation and feeding behaviour in lean men and women

Lookup NU author(s): Eileen Gibney


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AIM: Humans appear to defend against energy deficit to a greater extent than energy surplus. Severe dietary energy restriction resulting in 5-30% weight loss often leads to hyperphagia and weight regain in lean subjects. However, the period of time over which fasting is often endured in Western society are far shorter, ∼1-2 days. This study examined how a 36 h fast effected the subsequent day's energy and nutrient intake in a group of 24 healthy, lean men and women. METHOD: Subjects underwent two 2 day treatments, termed 'fast' and 'maintenance'. During the 'fast' treatment, subjects were fed a maintenance diet on the day prior to the fast (day -1) to prevent overeating. They then consumed non-energy drinks only, from 20:00h on day -1 to 08:00h on day 2 (ad libitum feeding day), thus fasting for 36h. On the 'maintenance' protocol, subjects received a maintenance diet throughout day 1. Throughout day 2 they had ad libitum access to a range of familiar foods, which were the same for both treatments. Body weight, blood glucose and respiratory quotient were used as compliance checks. Hunger was monitored on day's -1, 1 and 2 for the fast treatment only. RESULTS: On day 2, average energy intake was 10.2 vs 12.2 MJ/day (s.e.d. 1.0) on the post-maintenance and post-fast periods, respectively (P = 0.049). Subjects altered feeding behaviour, in response to the fast, only at breakfast time, selecting a higher-fat meal (P < 0.005). Compared to day -1, motivation to eat was elevated during the fast (P < 0.05). This continued until breakfast was consumed during the re-feeding period (day 2), when values then returned to baseline. CONCLUSION: These data suggest that a 36 h fast, which generated a negative energy balance of ∼ 12 MJ, did not induce a powerful, unconditioned stimulus to compensate on the subsequent day.

Publication metadata

Author(s): Johnstone AM, Faber P, Gibney ER, Elia M, Horgan G, Golden BE, Stubbs RJ

Publication type: Article

Publication status: Published

Journal: International Journal of Obesity

Year: 2002

Volume: 26

Issue: 12

Pages: 1623-1628

ISSN (print): 0307-0565

ISSN (electronic): 1476-5497

Publisher: Nature Publishing Group


DOI: 10.1038/sj.ijo.0802151

PubMed id: 12461679


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