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hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines

Lookup NU author(s): Dr Gabriele Saretzki, Professor Thomas von Zglinicki

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Abstract

Maintenance of telomeres, most often by telomerase, is a necessary prerequisite for immortality of eukaryotic cells. To better understand the mechanisms of telomerase up-regulation during tumorigenesis, we analysed the gene dosage of hTERT on chromosome 5p15, a region known to be overrepresented in a variety of malignancies, in 20 lung cancer cell lines by Southern blotting, fluorescence in-situ hybridization, and comparative genomic hybridization. We found a significant correlation between hTERT gene dosage, hTERT mRNA expression and telomerase activity. Imbalances of chromosome 5p may exert functionally relevant hTERT gene dosage effects in human lung cancer. © 2002 Elsevier Science Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Saretzki G, Petersen S, Petersen I, Kolble K, Von Zglinicki T

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 2002

Volume: 176

Issue: 1

Pages: 81-91

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0304-3835(01)00644-9

DOI: 10.1016/S0304-3835(01)00644-9

PubMed id: 11790457


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