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Lookup NU author(s): Dr Gabriele Saretzki,
Professor Thomas von Zglinicki
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Maintenance of telomeres, most often by telomerase, is a necessary prerequisite for immortality of eukaryotic cells. To better understand the mechanisms of telomerase up-regulation during tumorigenesis, we analysed the gene dosage of hTERT on chromosome 5p15, a region known to be overrepresented in a variety of malignancies, in 20 lung cancer cell lines by Southern blotting, fluorescence in-situ hybridization, and comparative genomic hybridization. We found a significant correlation between hTERT gene dosage, hTERT mRNA expression and telomerase activity. Imbalances of chromosome 5p may exert functionally relevant hTERT gene dosage effects in human lung cancer. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Author(s): Saretzki G, Petersen S, Petersen I, Kolble K, Von Zglinicki T
Publication type: Article
Publication status: Published
Journal: Cancer Letters
ISSN (print): 0304-3835
ISSN (electronic): 1872-7980
PubMed id: 11790457
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