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Lookup NU author(s): Emeritus Professor Harry Gilbert,
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The conformational reaction pathway for β-mannosidases proposed here is distinct from that of glucosidases and cellulases. The proposal is based on substrate distortions along the reaction pathway of a β-mannosidase (see picture) that were revealed by X-ray crystallography and are close in conformational space to known β-mannosidase inhibitors.
Author(s): Ducros VM-A, Zechel DL, Murshudov GN, Gilbert HJ, Szabo L, Stoll D, Withers SG, Davies GJ
Publication type: Article
Publication status: Published
Journal: Angewandte Chemie: International Edition
ISSN (print): 1433-7851
ISSN (electronic): 1521-3773
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
PubMed id: 12203498
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