Toggle Main Menu Toggle Search

Open Access padlockePrints

Non-invasive ventilation in motor neuron disease: Current UK practice

Lookup NU author(s): Professor Stephen BourkeORCiD, Dr Robert Bullock, Emeritus Professor John Gibson, Professor Pamela Shaw


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Objective: To evaluate the clinical application of non-invasive ventilation (NIV) in motor neuron disease (MND) in the UK. Method: We conducted a postal survey of the current clinical practice of all consultant neurologists in the UK, with a second mailing to non-responders after 6 weeks. The principal outcome measures assessed were: 1. the percentage of patients with MND receiving NIV, 2. access to a NIV service, 3. routine monitoring of respiratory function, and 4. influence of symptoms, respiratory function, rate of disease progression, level of disability and bulbar involvement on referral for NIV. Results: The response rate was 76%, 1719 new patients had been diagnosed in the preceding 12 months and a total of 2280 patients were under review. Of these, 126 were currently receiving NIV (5.5% of patients under review, estimated 2.6-3.5% of all MND patients). Most neurologists (172/265) had referred no patients for NIV in the preceding year, while three neurologists made 30% of all referrals nationally. Referral was based primarily on symptoms, and was influenced by the number of MND patients under review, level of disability, rate of disease progression and availability of a NIV service. Bulbar involvement was considered a relative contra-indication to NIV by 51 % of responders. Conclusions: In the UK, few patients with MND are treated with NIV. There is marked variation in clinical practice. This may reflect uncertainty about the role of non-invasive ventilation in MND, and emphasizes the need for a randomized controlled trial to assess the impact of NIV on quality of life and survival.

Publication metadata

Author(s): Bourke SC, Williams TL, Bullock RE, Gibson GJ, Shaw PJ

Publication type: Article

Publication status: Published

Journal: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

Year: 2002

Volume: 3

Issue: 3

Pages: 145-149

Print publication date: 01/09/2002

ISSN (print): 1466-0822

ISSN (electronic): 1471-180X

Publisher: Informa Healthcare


DOI: 10.1080/146608202760834157

PubMed id: 12495576


Altmetrics provided by Altmetric