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Telomerase inhibition as cancer therapy

Lookup NU author(s): Dr Gabriele Saretzki

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Abstract

A number of different approaches have been developed to inhibit telomerase activity in human cancer cells. Different components and types of inhibitors targeting various regulatory levels have been regarded as useful for telomerase inhibition. Most methods, however, rely on successive telomere shortening. This process is very slow and causes a long time lag between the onset of inhibition and the occurrence of senescence or apoptosis as a reversal of the immortal phenotype. Many telomerase inhibitors seem to be most efficient when combined with conventional chemotherapeutics. There are some promising approaches that seem to circumvent the slow way of telomere shortening and induce fast apoptosis in treated tumor cells. It has been demonstrated that telomerase may be involved in triggering apoptosis, but the underlying molecular mechanism remains unclear. © 2003 Elsevier Science Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Saretzki G

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 2003

Volume: 194

Issue: 2

Pages: 209-219

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0304-3835(02)00708-5

DOI: 10.1016/S0304-3835(02)00708-5

PubMed id: 12757979


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