Browse by author
Lookup NU author(s): Dr Hannah Cullup,
Professor Anne Dickinson,
Dr Jennifer Cavet,
Professor Graham Jackson,
Dr Peter Middleton
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The interleukin-1 (IL-1) family of cytokines is widely involved in inflammatory processes and diseases with an inflammatory component. Polymorphisms of the IL-1α, IL-1β and IL-1Ra genes have been implicated in a number of autoimmune or inflammatory conditions, with polymorphism of the IL-1Ra gene showing association with severity of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT). We compared the clinical outcomes (GVHD and survival) of 115 patients after human leucocyte antigen (HLA)-identical sibling allogeneic BMT with their genotype for two polymorphisms present in the IL-1α gene, which have been implicated in immune-related pathology. Possession of allele 2 of the IL-1α -889 polymorphism and allele 2 of the IL-1α variable number tandem repeat (VNTR) polymorphism in the donor genotype was associated with the occurrence of chronic, but not acute GVHD. A local normal population was also genotyped for these polymorphisms, and subsequent analysis identified conserved haplotypes in this gene region. Haplotypes containing allele 2 at both IL-1α -889 and IL-1α VNTR loci were extremely uncommon, suggesting that both risk alleles would be inherited independently. Both loci could therefore function as independent disease association markers. The polymorphisms of the IL-1α gene could be used to predict chronic GVHD in HLA-matched sibling transplants alongside clinical risk factors.
Author(s): Cullup H, Dickinson AM, Cavet J, Jackson GH, Middleton PG
Publication type: Article
Publication status: Published
Journal: British Journal of Haematology
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141
PubMed id: 12930389
Altmetrics provided by Altmetric