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No change in apoptosis in skeletal muscle exposed acutely or chronically to alcohol

Lookup NU author(s): Professor John Hesketh

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Abstract

The pathogenic mechanisms responsible for the deleterious changes in ethanol-exposed skeletal muscle are unknown, although apoptosis may be a causal process. We therefore investigated the responses of skeletal muscle to acute or chronic ethanol exposure in male Wistar rats. In acute studies, rats were dosed with ethanol (75 mmol (3.46 g)/kg BW) and killed after either 2.5 or 6 hours. In chronic studies, rats were fed ethanol as 35% of total dietary energy for 6 weeks. Apoptosis was determined by either DNA fragmentation or TUNEL (terminal deoxynucleotidyl transferase mediated dUTP nick end labelling) assays. The results showed that apoptosis was not increased in the ethanol-exposed muscle in both acute and chronic studies compared to appropriate controls.

Publication metadata

Author(s): Paice AG, Hesketh JE, Towner P, Hirako M, Peters TJ, Preedy VR

Publication type: Article

Publication status: Published

Journal: Addiction Biology

Year: 2003

Volume: 8

Issue: 1

Pages: 97-105

ISSN (print): 1355-6215

ISSN (electronic): 1369-1600

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1080/1355621031000069945

DOI: 10.1080/1355621031000069945

PubMed id: 12745422

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