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Browsing publications by Professor John Hesketh.

Newcastle AuthorsTitleYearFull text
Dr Catherine Meplan
Dr Wu Zhu
Professor John Hesketh
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status2019
Professor John Hesketh
Protective effects of selenium-glutathione-enriched probiotics on CCl4-induced liver fibrosis2018
Professor John Hesketh
Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line2017
Sadat Aziz
Dr Luisa Wakeling
Dr Satomi Miwa
Goiuri Alberdi Aresti
Professor John Hesketh
et al.
Metabolic programming of a beige adipocyte phenotype by genistein2017
Dr Anze Zupanic
Dr Catherine Meplan
Grazielle Huguenin
Professor John Hesketh
Dr Daryl Shanley
et al.
Modeling and gene knockdown to assess the contribution of nonsense-mediated decay, premature termination, and selenocysteine insertion to the selenoprotein hierarchy2016
Professor John Hesketh
Selenoprotein Gene Nomenclature2016
Dr Catherine Meplan
Dr Simon Cockell
David Bradburn
Dr Daniel Commane
Dr Ramesh Arasaradnam
et al.
Transcriptomics and proteomics show that selenium affects inflammation, cytoskeleton, and cancer pathways in human rectal biopsies2016
Professor John Hesketh
Dr Catherine Meplan
Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks' gestation in nulliparous women who subsequently develop preeclampsia2015
Dr Catherine Meplan
Professor John Hesketh
Association of selenoprotein and selenium pathway gene variation with colorectal cancer risk and modification by selenium status2015
Dr Catherine Meplan
Professor John Hesketh
Association of selenoprotein and selenium pathway genetic variations with colorectal cancer risk and interaction with selenium status2015
Sadat Aziz
Dr Satomi Miwa
Professor John Hesketh
Professor Dianne Ford
Induction by genistein of a gene expression profile in mouse NIH3T3-L1 cells indicating conversion of white to beige adipocytes2015
Dr Emma Bermingham
Professor John Hesketh
Anna Maciel Dominguez
Low Folate and Selenium in the Mouse Maternal Diet Alters Liver Gene Expression Patterns in the Offspring after Weaning2015
Professor John Hesketh
Dr Patience Ezea
Ochratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo2015
Dr Catherine Meplan
Professor John Hesketh
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort2015
Professor Georg Lietz
Dr Anthony Oxley
Phil Berry
Professor John Hesketh
Dr Franck Tourniaire
et al.
β-carotene (BC) bioconversion is similar in men and women2015
Dr Anthony Oxley
Phil Berry
Gordon Taylor
Dr Joe Cowell
Dr Michael Hall
et al.
An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion and vitamin A status in humans2014
Dr Anze Zupanic
Dr Catherine Meplan
Dr Sushma Grellscheid
Professor John Mathers
Emeritus Professor Thomas Kirkwood
et al.
Detecting translational regulation by change point analysis of ribosome profiling data sets2014
Sadat Aziz
Dr Luisa Wakeling
Professor John Hesketh
Professor Dianne Ford
Genistein promotes a gene expression profile characteristic of brown rather than white adipocytes and increases Sirt1 expression in mouse NIH3T3-L1 cells2014
Dr Catherine Meplan
Professor John Hesketh
Selenium and cancer: a story that should not be forgotten-insights from genomics.2014
Dr Emma Bermingham
Professor John Hesketh
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis2014
Dr Catherine Meplan
Professor John Hesketh
Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk2013
Dr Anthony Oxley
Phil Berry
Professor John Hesketh
Professor Alan Boddy
Professor Georg Lietz
et al.
Gender differences in retinol metabolism are independent of β-carotene bioconversion2013
Anna Maciel Dominguez
Dr Daniel Swan
Professor Dianne Ford
Professor John Hesketh
Selenium alters miRNA profile in an intestinal cell line: Evidence that miR-185 regulates expression of GPX2 and SEPSH22013
Lynne Crosley
Professor John Hesketh
The Single-Nucleotide Polymorphism (GPX4c718t) in the Glutathione Peroxidase 4 Gene Influences Endothelial Cell Function: Interaction with Selenium and Fatty Acids2013
Mark Pearson
Dr Siavash Khazaipoul
Professor John Hesketh
Albumin 3'untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells2012
Dr Catherine Meplan
Professor John Hesketh
Colorectal Cancer Risk - the Influence of Selenoprotein Gene Variants and Blood Selenium Status2012
Professor John Hesketh
CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region2012
Guanyu Gong
Dr Catherine Meplan
Dr Hannah Gautrey
Dr Judith Hall
Professor John Hesketh
et al.
Differential effects of selenium and knock-down of glutathione peroxidases on TNF alpha and flagellin inflammatory responses in gut epithelial cells2012
Dr Daniel Swan
Dr Daryl Shanley
Professor John Hesketh
Glutathione Peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells2012
Dr Catherine Meplan
Professor John Hesketh
Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer2012
Professor Georg Lietz
Dr Anthony Oxley
Professor John Hesketh
Single Nucleotide Polymorphisms Upstream from the β-Carotene 15,15'-Monoxygenase Gene Influence Provitamin A Conversion Efficiency in Female Volunteers2012
Dr Luisa Wakeling
Professor John Hesketh
Professor Dianne Ford
SIRT1-independent epigenetic effects of resveratrol mediated through the estrogen receptor2012
Dr Luisa Wakeling
Fatema AlAtawi
Laura Ions
Professor John Hesketh
Professor Dianne Ford
et al.
SIRT1-independent epigenetic effects of resveratrol mediated through the estrogen receptor2012
Dr Hannah Gautrey
Dr Judith Hall
Professor John Hesketh
A T/C polymorphism in the GPX4 3 ' UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells2011
Professor Dianne Ford
Professor John Hesketh
Selenium in Human Health and Disease2011
Dr Catherine Meplan
Professor John Hesketh
Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men2010
Dr Catherine Meplan
Professor John Hesketh
Genetic variants in selenoprotein genes increase risk of colorectal cancer2010
Dr Fiona Caple
Dr Liz Williams
Dr Alison Spiers
Dr John Tyson
Brian Burtle
et al.
Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype2010
Professor John Mathers
Dr Catherine Meplan
Professor John Hesketh
Polymorphisms Affecting Trace Element Bioavailability2010
Dr Alison Sutherland
David Kim
Professor Caroline Relton
Professor John Hesketh
Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer2010
Professor John Hesketh
Professor Georg Lietz
Professor John Mathers
Dr Catherine Meplan
The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research2010
Professor John Hesketh
The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes2010
Professor John Hesketh
Professor Georg Lietz
A network approach to micronutrient genetics: interactions with lipid metabolism2009
Professor Zofia Chrzanowska-Lightowlers
Professor John Hesketh
Fine mapping of interactions between eEF1 alpha protein and 3 ' UTR of metallothionein-1 mRNA2009
Dr Catherine Meplan
Professor John Hesketh
Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon2009
Dr John Tyson
Dr Fiona Caple
Dr Alison Spiers
Brian Burtle
Professor Ann Daly
et al.
Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype2009
Dr Catherine Meplan
Brian Burtle
Professor John Mathers
Professor John Hesketh
Relative Abundance of Selenoprotein P Isoforms in Human Plasma Depends on Genotype, Se Intake, and Cancer Status2009
Dr Catherine Meplan
Dr James Flint
Dr Franck Tourniaire
Professor John Hesketh
Professor Georg Lietz
et al.
Two common single nucleotide polymorphisms in the gene encoding β-carotene 15,15′-monoxygenase alter β-carotene metabolism in female volunteers2009
Dr Franck Tourniaire
Professor John Hesketh
Professor Georg Lietz
Do single nucleotide polymorphisms in beta-carotene dioxygenase-2 ( BCDO2) gene affect the postprandial response?2008
Dr Catherine Meplan
Professor John Mathers
Professor John Hesketh
Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: Interaction with sex2008
Professor John Hesketh
Nutrigenomics and selenium: Gene expression patterns, physiological targets, and genetics2008
Dr Hannah Gautrey
Professor Majlinda Lako
Dr Judith Hall
Professor John Hesketh
Staufen1 is expressed in preimplantation mouse embryos and is required for embryonic stem cell differentiation2008
Vasileios Pagmantidis
Dr Catherine Meplan
Professor John Hesketh
Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes2008
Christopher Pedder
Professor Dianne Ford
Professor John Hesketh
Targeting of transcripts encoding membrane proteins in polarized epithelia: RNA-protein binding studies of the SGLT1 3′-UTR2008
Professor John Hesketh
Professor Georg Lietz
The challenges for molecular nutrition research 1: Linking genotype to healthy nutrition2008
Vasileios Pagmantidis
Professor John Hesketh
Assessment of reducing RNA input for Agilent oligo microarrays2007
Dr Catherine Meplan
Professor John Hesketh
Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney2007
Vasileios Pagmantidis
Dr Robert Shiel
Professor John Mathers
Professor Ann Daly
Professor John Hesketh
et al.
Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer2007
Professor John Hesketh
Nutrigenomic approaches for benefit-risk analysis of foods and food components: Defining markers of health2007
Professor John Hesketh
Professor John Mathers
Personalised nutrition: Status and perspectives2007
Professor John Mathers
Professor John Hesketh
The biological revolution: Understanding the impact of SNPs on diet-cancer interrelationships2007
Professor John Mathers
Professor John Hesketh
The Biological Revolution: Understanding the Impact of SNPs on Diet-Cancer Interrelationships2007
Dr Catherine Meplan
Professor John Mathers
Professor John Hesketh
A polymorphism in the coding region of human selenoprotein P gene influences the response to selenium supplementation in healthy volunteers2006
Dr John Tyson
Dr Alison Spiers
Dr Fiona Caple
Professor John Hesketh
Professor John Mathers
et al.
Effects of age, body mass index and genotype on nucleotide excision repair in healthy adults2006
Dr Ian Mickleburgh
Dr Herve Chabanon
David Nury
Brian Burtle
Professor Zofia Chrzanowska-Lightowlers
et al.
Elongation factor 1α binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization - Importance of an internal stem-loop2006
Paul Sanderson
Professor John Hesketh
Dr Margaret Jackson
Functional markers of selenium status: UK Food Standards Agency workshop report2006
Dr Catherine Meplan
Professor John Mathers
Professor John Hesketh
Influences of gender and genetic variation in the 3 ' untranslated region of the glutathione peroxidise 4 gene on the response to selenium supplementation in healthy volunteers2006
Professor John Hesketh
Nutrient-gene interactions in benefit-risk analysis2006
Adrian Blackburn
Dr Herve Chabanon
Professor John Hesketh
Perinuclear localisation of cellular retinoic acid binding protein I mRNA2006
Professor John Hesketh
An AU-rich stem-loop structure is a critical feature of the perinuclear localization signal of c-myc mRNA2005
David Nury
Dr Herve Chabanon
Professor John Hesketh
An eleven nucleotide section of the 3′- untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA2005
Professor Zofia Chrzanowska-Lightowlers
Professor John Hesketh
Annexin A2 binds to the localization signal in the 3′ untranslated region of c-myc mRNA2005
Vasileios Pagmantidis
Dr Stephane Villette
Professor John Hesketh
Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon2005
Dr John Tyson
Dr Alison Spiers
Dr Fiona Caple
Professor John Hesketh
Professor John Mathers
et al.
Inter-individual variation in nucleotide excision repair capacity: potential scope for dietary modulation of DNA repair2005
Emeritus Professor Chris Seal
Professor John Hesketh
Patients with ulcerative colitis show an altered frequency distribution of a single novel polymorphism (SNP) in the gene encoding the phospholipid hydroperoxide glutathione peroxidase 4 (GPX4)2005
Dr Hannah Gautrey
Dr Judith Hall
Professor John Hesketh
Polarised distribution of the RNA-binding protein Staufen in differentiated intestinal epithelial cells2005
Dr Herve Chabanon
David Nury
Dr Ian Mickleburgh
Brian Burtle
Professor John Hesketh
et al.
Characterization of the cis-acting element directing perinuclear localization of the metallothionein-1 mRNA2004
Vasileios Pagmantidis
Professor John Hesketh
Glutathione peroxidase 4 gene polymorphism and susceptibility to colorectal cancer2004
Dr Ian Mickleburgh
Brian Burtle
David Nury
Dr Herve Chabanon
Professor Zofia Chrzanowska-Lightowlers
et al.
Isolation and identification of a protein binding to the localization element of Metallothionein-1 mRNA2004
Professor John Hesketh
Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores2004
Dr Herve Chabanon
Dr Ian Mickleburgh
Professor John Hesketh
Zipcodes and postage stamps: mRNA localisation signals and their trans-acting binding proteins2004
Professor John Hesketh
No change in apoptosis in skeletal muscle exposed acutely or chronically to alcohol2003
Dr Stephane Villette
Professor John Hesketh
A novel single nucleotide polymorphism in the 3′ untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism2002
Professor John Hesketh
Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle2002
Professor John Hesketh
Dr Stephane Villette
Intracellular trafficking of micronutrients: from gene regulation to nutrient requirements2002
Professor John Hesketh
Metal- and tissue-dependent relationship between metallothionein mRNA and protein2002
Professor John Hesketh
Dr Stephane Villette
Symposium on 'nutrition in the post-genomic era' plenary session 2: Nutrient regulation of gene expression: Intracellular trafficking of micronutrients: From gene regulation to nutrient requirements2002
Dr Marilyne Levadoux
Professor John Hesketh
Influence of metallothionein on its function2001
Professor John Hesketh
mRNA Localization by a 145-nucleotide region of the c-fos 3′-untranslated region: Links to translation but not stability2001
Professor John Hesketh
Perinuclear mRNA localisation by vimentin 3 '-untranslated region requires a 100 nucleotide sequence and intermediate filaments2001
Dr Marilyne Levadoux
Professor John Hesketh
Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton1999