Publications by Professor John Hesketh - ePrints

Browsing publications by Professor John Hesketh.

Newcastle Authors	Title	Year
Dr Catherine Meplan Dr Wu Zhu Professor John Hesketh	Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status	2019
Professor John Hesketh	Protective effects of selenium-glutathione-enriched probiotics on CCl₄-induced liver fibrosis	2018
Professor John Hesketh	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line	2017
Sadat Aziz Dr Luisa Wakeling Dr Satomi Miwa Goiuri Alberdi Aresti Professor John Hesketh et al.	Metabolic programming of a beige adipocyte phenotype by genistein	2017
Dr Anze Zupanic Dr Catherine Meplan Grazielle Huguenin Professor John Hesketh Dr Daryl Shanley et al.	Modeling and gene knockdown to assess the contribution of nonsense-mediated decay, premature termination, and selenocysteine insertion to the selenoprotein hierarchy	2016
Professor John Hesketh	Selenoprotein Gene Nomenclature	2016
Dr Catherine Meplan Dr Simon Cockell David Bradburn Dr Daniel Commane Dr Ramesh Arasaradnam et al.	Transcriptomics and proteomics show that selenium affects inflammation, cytoskeleton, and cancer pathways in human rectal biopsies	2016
Professor John Hesketh Dr Catherine Meplan	Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks' gestation in nulliparous women who subsequently develop preeclampsia	2015
Dr Catherine Meplan Professor John Hesketh	Association of selenoprotein and selenium pathway gene variation with colorectal cancer risk and modification by selenium status	2015
Dr Catherine Meplan Professor John Hesketh	Association of selenoprotein and selenium pathway genetic variations with colorectal cancer risk and interaction with selenium status	2015
Sadat Aziz Dr Satomi Miwa Professor John Hesketh Professor Dianne Ford	Induction by genistein of a gene expression profile in mouse NIH3T3-L1 cells indicating conversion of white to beige adipocytes	2015
Dr Emma Bermingham Professor John Hesketh Anna Maciel Dominguez	Low Folate and Selenium in the Mouse Maternal Diet Alters Liver Gene Expression Patterns in the Offspring after Weaning	2015
Professor John Hesketh Dr Patience Ezea	Ochratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo	2015
Dr Catherine Meplan Professor John Hesketh	Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort	2015
Professor Georg Lietz Dr Anthony Oxley Philip Berry Professor John Hesketh Dr Franck Tourniaire et al.	β-carotene (BC) bioconversion is similar in men and women	2015
Dr Anthony Oxley Philip Berry Gordon Taylor Dr Joe Cowell Dr Michael Hall et al.	An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion and vitamin A status in humans	2014
Dr Anze Zupanic Dr Catherine Meplan Dr Sushma Grellscheid Professor John Mathers Emeritus Professor Thomas Kirkwood et al.	Detecting translational regulation by change point analysis of ribosome profiling data sets	2014
Sadat Aziz Dr Luisa Wakeling Professor John Hesketh Professor Dianne Ford	Genistein promotes a gene expression profile characteristic of brown rather than white adipocytes and increases Sirt1 expression in mouse NIH₃T₃-L1 cells	2014
Dr Catherine Meplan Professor John Hesketh	Selenium and cancer: a story that should not be forgotten-insights from genomics.	2014
Dr Emma Bermingham Professor John Hesketh	Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis	2014
Dr Catherine Meplan Professor John Hesketh	Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk	2013
Dr Anthony Oxley Philip Berry Professor John Hesketh Professor Alan Boddy Professor Georg Lietz et al.	Gender differences in retinol metabolism are independent of β-carotene bioconversion	2013
Anna Maciel Dominguez Dr Daniel Swan Professor Dianne Ford Professor John Hesketh	Selenium alters miRNA profile in an intestinal cell line: Evidence that miR-185 regulates expression of GPX2 and SEPSH2	2013
Lynne Crosley Professor John Hesketh	The Single-Nucleotide Polymorphism (GPX4c718t) in the Glutathione Peroxidase 4 Gene Influences Endothelial Cell Function: Interaction with Selenium and Fatty Acids	2013
Mark Pearson Dr Siavash Khazaipoul Professor John Hesketh	Albumin 3'untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells	2012
Dr Catherine Meplan Professor John Hesketh	Colorectal Cancer Risk - the Influence of Selenoprotein Gene Variants and Blood Selenium Status	2012
Professor John Hesketh	CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region	2012
Guanyu Gong Dr Catherine Meplan Dr Hannah Gautrey Dr Judith Hall Professor John Hesketh et al.	Differential effects of selenium and knock-down of glutathione peroxidases on TNF alpha and flagellin inflammatory responses in gut epithelial cells	2012
Dr Daniel Swan Dr Daryl Shanley Professor John Hesketh	Glutathione Peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells	2012
Dr Catherine Meplan Professor John Hesketh	Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer	2012
Professor Georg Lietz Dr Anthony Oxley Professor John Hesketh	Single Nucleotide Polymorphisms Upstream from the β-Carotene 15,15'-Monoxygenase Gene Influence Provitamin A Conversion Efficiency in Female Volunteers	2012
Dr Luisa Wakeling Professor John Hesketh Professor Dianne Ford	SIRT1-independent epigenetic effects of resveratrol mediated through the estrogen receptor	2012
Dr Luisa Wakeling Fatema AlAtawi Laura Ions Professor John Hesketh Professor Dianne Ford et al.	SIRT1-independent epigenetic effects of resveratrol mediated through the estrogen receptor	2012
Dr Hannah Gautrey Dr Judith Hall Professor John Hesketh	A T/C polymorphism in the GPX4 3 ' UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells	2011
Professor Dianne Ford Professor John Hesketh	Selenium in Human Health and Disease	2011
Dr Catherine Meplan Professor John Hesketh	Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men	2010
Dr Catherine Meplan Professor John Hesketh	Genetic variants in selenoprotein genes increase risk of colorectal cancer	2010
Dr Fiona Caple Dr Liz Williams Dr Alison Spiers Dr John Tyson Brian Burtle et al.	Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype	2010
Professor John Mathers Dr Catherine Meplan Professor John Hesketh	Polymorphisms Affecting Trace Element Bioavailability	2010
Dr Alison Sutherland David Kim Professor Caroline Relton Professor John Hesketh	Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer	2010
Professor John Hesketh Professor Georg Lietz Professor John Mathers Dr Catherine Meplan	The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research	2010
Professor John Hesketh	The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes	2010
Professor John Hesketh Professor Georg Lietz	A network approach to micronutrient genetics: interactions with lipid metabolism	2009
Professor Zofia Chrzanowska-Lightowlers Professor John Hesketh	Fine mapping of interactions between eEF1 alpha protein and 3 ' UTR of metallothionein-1 mRNA	2009
Dr Catherine Meplan Professor John Hesketh	Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon	2009
Dr John Tyson Dr Fiona Caple Dr Alison Spiers Brian Burtle Professor Ann Daly et al.	Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype	2009
Dr Catherine Meplan Brian Burtle Professor John Mathers Professor John Hesketh	Relative Abundance of Selenoprotein P Isoforms in Human Plasma Depends on Genotype, Se Intake, and Cancer Status	2009
Dr Catherine Meplan Dr James Flint Dr Franck Tourniaire Professor John Hesketh Professor Georg Lietz et al.	Two common single nucleotide polymorphisms in the gene encoding β-carotene 15,15′-monoxygenase alter β-carotene metabolism in female volunteers	2009
Dr Franck Tourniaire Professor John Hesketh Professor Georg Lietz	Do single nucleotide polymorphisms in beta-carotene dioxygenase-2 ( BCDO2) gene affect the postprandial response?	2008
Dr Catherine Meplan Professor John Mathers Professor John Hesketh	Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: Interaction with sex	2008
Professor John Hesketh	Nutrigenomics and selenium: Gene expression patterns, physiological targets, and genetics	2008
Dr Hannah Gautrey Professor Majlinda Lako Dr Judith Hall Professor John Hesketh	Staufen1 is expressed in preimplantation mouse embryos and is required for embryonic stem cell differentiation	2008
Vasileios Pagmantidis Dr Catherine Meplan Professor John Hesketh	Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes	2008
Christopher Pedder Professor Dianne Ford Professor John Hesketh	Targeting of transcripts encoding membrane proteins in polarized epithelia: RNA-protein binding studies of the SGLT1 3′-UTR	2008
Professor John Hesketh Professor Georg Lietz	The challenges for molecular nutrition research 1: Linking genotype to healthy nutrition	2008
Vasileios Pagmantidis Professor John Hesketh	Assessment of reducing RNA input for Agilent oligo microarrays	2007
Dr Catherine Meplan Professor John Hesketh	Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney	2007
Vasileios Pagmantidis Dr Robert Shiel Professor John Mathers Professor Ann Daly Professor John Hesketh et al.	Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer	2007
Professor John Hesketh	Nutrigenomic approaches for benefit-risk analysis of foods and food components: Defining markers of health	2007
Professor John Hesketh Professor John Mathers	Personalised nutrition: Status and perspectives	2007
Professor John Mathers Professor John Hesketh	The biological revolution: Understanding the impact of SNPs on diet-cancer interrelationships	2007
Professor John Mathers Professor John Hesketh	The Biological Revolution: Understanding the Impact of SNPs on Diet-Cancer Interrelationships	2007
Dr Catherine Meplan Professor John Mathers Professor John Hesketh	A polymorphism in the coding region of human selenoprotein P gene influences the response to selenium supplementation in healthy volunteers	2006
Dr John Tyson Dr Alison Spiers Dr Fiona Caple Professor John Hesketh Professor John Mathers et al.	Effects of age, body mass index and genotype on nucleotide excision repair in healthy adults	2006
Dr Ian Mickleburgh Dr Herve Chabanon David Nury Brian Burtle Professor Zofia Chrzanowska-Lightowlers et al.	Elongation factor 1α binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization - Importance of an internal stem-loop	2006
Paul Sanderson Professor John Hesketh Dr Margaret Jackson	Functional markers of selenium status: UK Food Standards Agency workshop report	2006
Dr Catherine Meplan Professor John Mathers Professor John Hesketh	Influences of gender and genetic variation in the 3 ' untranslated region of the glutathione peroxidise 4 gene on the response to selenium supplementation in healthy volunteers	2006
Professor John Hesketh	Nutrient-gene interactions in benefit-risk analysis	2006
Adrian Blackburn Dr Herve Chabanon Professor John Hesketh	Perinuclear localisation of cellular retinoic acid binding protein I mRNA	2006
Professor John Hesketh	An AU-rich stem-loop structure is a critical feature of the perinuclear localization signal of c-myc mRNA	2005
David Nury Dr Herve Chabanon Professor John Hesketh	An eleven nucleotide section of the 3′- untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA	2005
Professor Zofia Chrzanowska-Lightowlers Professor John Hesketh	Annexin A2 binds to the localization signal in the 3′ untranslated region of c-myc mRNA	2005
Vasileios Pagmantidis Dr Stephane Villette Professor John Hesketh	Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon	2005
Dr John Tyson Dr Alison Spiers Dr Fiona Caple Professor John Hesketh Professor John Mathers et al.	Inter-individual variation in nucleotide excision repair capacity: potential scope for dietary modulation of DNA repair	2005
Emeritus Professor Chris Seal Professor John Hesketh	Patients with ulcerative colitis show an altered frequency distribution of a single novel polymorphism (SNP) in the gene encoding the phospholipid hydroperoxide glutathione peroxidase 4 (GPX4)	2005
Dr Hannah Gautrey Dr Judith Hall Professor John Hesketh	Polarised distribution of the RNA-binding protein Staufen in differentiated intestinal epithelial cells	2005
Dr Herve Chabanon David Nury Dr Ian Mickleburgh Brian Burtle Professor John Hesketh et al.	Characterization of the cis-acting element directing perinuclear localization of the metallothionein-1 mRNA	2004
Vasileios Pagmantidis Professor John Hesketh	Glutathione peroxidase 4 gene polymorphism and susceptibility to colorectal cancer	2004
Dr Ian Mickleburgh Brian Burtle David Nury Dr Herve Chabanon Professor Zofia Chrzanowska-Lightowlers et al.	Isolation and identification of a protein binding to the localization element of Metallothionein-1 mRNA	2004
Professor John Hesketh	Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores	2004
Dr Herve Chabanon Dr Ian Mickleburgh Professor John Hesketh	Zipcodes and postage stamps: mRNA localisation signals and their trans-acting binding proteins	2004
Professor John Hesketh	No change in apoptosis in skeletal muscle exposed acutely or chronically to alcohol	2003
Dr Stephane Villette Professor John Hesketh	A novel single nucleotide polymorphism in the 3′ untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism	2002
Professor John Hesketh	Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle	2002
Professor John Hesketh Dr Stephane Villette	Intracellular trafficking of micronutrients: from gene regulation to nutrient requirements	2002
Professor John Hesketh	Metal- and tissue-dependent relationship between metallothionein mRNA and protein	2002
Professor John Hesketh Dr Stephane Villette	Symposium on 'nutrition in the post-genomic era' plenary session 2: Nutrient regulation of gene expression: Intracellular trafficking of micronutrients: From gene regulation to nutrient requirements	2002
Dr Marilyne Levadoux Professor John Hesketh	Influence of metallothionein on its function	2001
Professor John Hesketh	mRNA Localization by a 145-nucleotide region of the c-fos 3′-untranslated region: Links to translation but not stability	2001
Professor John Hesketh	Perinuclear mRNA localisation by vimentin 3 '-untranslated region requires a 100 nucleotide sequence and intermediate filaments	2001
Dr Marilyne Levadoux Professor John Hesketh	Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton	1999