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Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

Lookup NU author(s): Gavin Pell, Emeritus Professor Harry Gilbert

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Abstract

A cellobio-derived isofagomine glycosidase inhibitor (Ki ∼400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

Publication metadata

Author(s): Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2003

Volume: 9

Issue: 8

Pages: 946-947

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/b301592k

DOI: 10.1039/b301592k

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