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Anti-cancer effects of butyrate: Use of micro-array technology to investigate mechanisms

Lookup NU author(s): Dr Liz Williams, Dr Jonathan Coxhead, Professor John Mathers


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Epidemiological evidence suggests that a high intake of resistant starch and NSP protects against colo-rectal cancer. The mechanisms underlying this protection are thought to be mediated by the short-chain fatty acid butyrate, which is present in the colonic lumen in millimolar concentrations as a result of bacterial fermentation of carbohydrates that have resisted digestion in the small intestine. In vitro studies have shown that butyrate displays a host of chemo-preventative properties including increased apoptosis, reduced proliferation, down regulation of angiogenesis, enhanced immunosurveillance and anti-inflammatory effects in colo-rectal cancer cell lines. However, the molecular mechanisms underlying the apparent chemo-preventative actions of butyrate are largely unknown. The evidence supporting the role of butyrate as an anti-cancer agent is reviewed, with particular emphasis on those studies that have attempted to elucidate the mechanism of action of butyrate. Our understanding of the mechanistic action of butyrate and its role in cancer prevention is likely to advance considerably in this post-genomic era with the application of genomic and proteomic technologies. Studies are described that have used gene array and proteomic techniques to investigate the response of colo-rectal cancer cells to butyrate. These pioneering studies illustrate the potential of these technologies to help characterise the molecular responses of the cancer cell to butyrate, and to define the role of butyrate (and other nutrients) in the prevention of colo-rectal cancer.

Publication metadata

Author(s): Williams EA, Coxhead JM, Mathers JC

Publication type: Article

Publication status: Published

Journal: Proceedings of the Nutrition Society

Year: 2003

Volume: 62

Issue: 1

Pages: 107-115

Print publication date: 01/02/2003

ISSN (print): 0029-6651

ISSN (electronic): 1475-2719

Publisher: Cambridge University Press


DOI: 10.1079/PNS2002230

PubMed id: 12740065


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Funder referenceFunder name
D20173Biotechnology and Biological Sciences Research Council