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Lookup NU author(s): Professor Farhad Kamali,
Professor Ann Daly,
Dr Hilary Wynne
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Background: Avoidance of over anticoagulation in response to warfarin therapy would reduce risk of associated bleeding. Subjects: 5wo elderly patients with venous thromboembolism exhibited extreme anticoagulant response to warfarin. Both were noted to have variant CYP2C9 alleles, which reduce the metabolic capacity of cytochrome P450 2C9. Discussion: Adverse outcomes with warfarin therapy could be explained and possibly avoided by identifying patients with variant alleles for CYP2C9 before initiation of therapy.
Author(s): Khan T, Kamali F, Daly A, King B, Wynne HA
Publication type: Article
Publication status: Published
Journal: Age and Ageing
Print publication date: 01/03/2003
ISSN (print): 0002-0729
ISSN (electronic): 1468-2834
Publisher: Oxford University Press
PubMed id: 12615570
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