ePrints

Warfarin sensitivity: Be aware of genetic influence

Lookup NU author(s): Professor Farhad Kamali, Professor Ann DalyORCiD, Dr Hilary Wynne

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Background: Avoidance of over anticoagulation in response to warfarin therapy would reduce risk of associated bleeding. Subjects: 5wo elderly patients with venous thromboembolism exhibited extreme anticoagulant response to warfarin. Both were noted to have variant CYP2C9 alleles, which reduce the metabolic capacity of cytochrome P450 2C9. Discussion: Adverse outcomes with warfarin therapy could be explained and possibly avoided by identifying patients with variant alleles for CYP2C9 before initiation of therapy.

Publication metadata

Author(s): Khan T, Kamali F, Daly A, King B, Wynne HA

Publication type: Article

Publication status: Published

Journal: Age and Ageing

Year: 2003

Volume: 32

Issue: 2

Pages: 226-227

Print publication date: 01/03/2003

ISSN (print): 0002-0729

ISSN (electronic): 1468-2834

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/ageing/32.2.226

DOI: 10.1093/ageing/32.2.226

PubMed id: 12615570

Altmetrics

Share