Browse by author
Lookup NU author(s): Suzanne Senior, Dr Petr Illarionov, Dr Sudagar Gurcha, Professor David Minnikin, Professor Del Besra
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Analogues of the antibiotic thiolactomycin, with biphenyl-based 5-substituents, were found to have excellent in vitro inhibitory activity against the recombinant Mycobacterium tuberculosis β-ketoacyl-ACP synthase mtFabH condensing enzyme. In particular, 5-(4′ -benzyloxy-biphen-4-ylmethyl)-4-hydroxy-3,5-dimethyl-5H-thiophen-2-one exhibited approximately a 4-fold increased potency against this key condensing enzyme involved in M. tuberculosis mycolic acid biosynthesis, compared to thiolactomycin. © 2003 Elsevier Ltd. All rights reserved.
Author(s): Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS
Publication type: Article
Publication status: Published
Journal: Bioorganic and Medicinal Chemistry Letters
Year: 2003
Volume: 13
Issue: 21
Pages: 3685-3688
ISSN (print): 0960-894X
ISSN (electronic): 1464-3405
Publisher: Pergamon
URL: http://dx.doi.org/v
DOI: 10.1016/j.bmcl.2003.08.015
PubMed id: 14552758
Altmetrics provided by Altmetric