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Estimation of glomerular filtration rate in paediatric cancer patients using 51CR-EDTA population pharmacokinetics

Lookup NU author(s): Mike Cole, Annie Parry, Dr Michael Keir, Professor Andrew Pearson, Professor Alan Boddy, Professor Gareth Veal

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Abstract

Estimation of glomerular filtration rate (GFR) using the clearance of chromium 51 EDTA (51Cr-EDTA) (or other radiolabelled isotopes) is reliable, but invasive and not always practicable. Mathematical models have been devised for estimating GFR using readily obtainable patient characteristics. Unfortunately, these models were developed using various patient populations and may not provide the optimal prediction of GFR in children with cancer. The current study uses population pharmacokinetics to determine the relationship between 51Cr-EDTA clearance, and patient covariates in 50 paediatric cancer patients. These models were validated using a separate group of 43 children and were compared with previously published models of renal function. Body size was the major determinant of 51Cr-EDTA clearance and inclusion of weight or surface area reduced the residual variability between individuals (coefficient of variation) from 61 to 32%. Serum creatinine was the only other parameter that significantly improved the model. Mean percentage error values of -5.0 and -1.1% were observed for models including weight alone or weight and creatinine, respectively, with precision estimates of 21.7 and 20.0%. These simple additive models provide a more rationale approach than the use of complex formulae, involving additional parameters, to predict renal function. © 2004 Cancer Research UK.


Publication metadata

Author(s): Cole M, Price L, Parry AP, Keir M, Pearson ADJ, Boddy A V, Veal GJ

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 2004

Volume: 90

Issue: 1

Pages: 60-64

Print publication date: 12/01/2004

Date deposited: 04/08/2010

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.bjc.6601484

DOI: 10.1038/sj.bjc.6601484

PubMed id: 14710207


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