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A perspective on inversin

Lookup NU author(s): Dr Lorraine Eley, Lee Turnpenny, Dr Laura Yates, Scott Craighead, David Morgan, Professor Judith Goodship, Professor Tom Strachan

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Abstract

Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left-right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left-right axis and renal function remains to be elucidated. © 2004 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Eley L, Turnpenny L, Yates LM, Craighead AS, Morgan D, Whistler C, Goodship JA, Strachan T

Publication type: Review

Publication status: Published

Journal: Cell Biology International

Year: 2004

Volume: 28

Issue: 2

Pages: 119-124

Print publication date: 01/01/2004

ISSN (print): 1065-6995

ISSN (electronic): 1095-8355

URL: http://dx.doi.org/10.1016/j.cellbi.2003.11.009

DOI: 10.1016/j.cellbi.2003.11.009

PubMed id: 14984757


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