Browse by author
Lookup NU author(s): Dr Hannah Cullup, Dr Peter Middleton, Professor Anne Dickinson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Cytokine production may be regulated by both genotypic (single nucleotide or tandem repeat polymorphisms) and non-genotypic factors relating to the environment and inherent biology (i.e. gender). Interleukin (IL)-1 is one of the body's most highly proinflammatory cytokines and is implicated in the pathophysiology of numerous diseases, but also in the maintenance of homeostasis in a number of tissues. The cytokine IL-1 receptor antagonist (IL-1Ra) is the competitive inhibitor of the IL-1 agonists IL-1α and IL-1β, In vivo IL-1Ra was measured in a cohort of 200 + blood donors and the effect of the IL-1 gene polymorphisms, environmental and biological factors assessed. In this study, we observed that possession of particular alleles of 5 IL-1 gene polymorphisms (IL1A-889, IL1A VNTR, IL1B -511, IL1B +3953 and the IL1RN VNTR) did not correlate with higher plasma IL-1Ra levels. Environmental factors such as smoking and non-steroidal anti-inflammatory drug ingestion were associated with higher in vivo IL-1Ra levels (P= 0.015 and 0.022, respectively), but biological factors such as gender, age and menstruation status did not have any impact upon in vivo IL-1Ra levels. Genotypic associations of IL-1 gene family polymorphisms with disease features may reflect characteristics of stressed rather than normal control circuits for cytokine production.
Author(s): Cullup H, Middleton PG, Duggan G, Conn JS, Dickinson AM
Publication type: Article
Publication status: Published
Journal: Clinical and Experimental Immunology
Year: 2004
Volume: 137
Issue: 2
Pages: 351-358
Print publication date: 01/08/2004
ISSN (print): 0009-9104
ISSN (electronic): 1365-2249
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1111/j.1365-2249.2004.02531.x
DOI: 10.1111/j.1365-2249.2004.02531.x
PubMed id: 15270852
Altmetrics provided by Altmetric
