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Lookup NU author(s): Richard Cooke, Dr Alan Fenton
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Background: Previous data from this unit suggest that postnatal growth retardation (PGR) is inevitable in preterm infants. However, the study was performed in a single level III neonatal intensive care unit and applicability of the findings to other level III or level I-II special care baby units was uncertain. Objectives: To examine postnatal hospital growth and to compare growth outcome in preterm infants discharged from four level III tertiary care units and 10 level I-II special care baby units in the former Northern Region of the United Kingdom. Subjects/methods: Preterm infants (≤ 32 weeks gestation; ≤ 1500 g) surviving to discharge were studied. Infants were weighed at birth and discharge. Body weight was converted into a z score using the British Foundation Growth Standards. To ascertain the degree of PGR, the z score at birth was subtracted from the z score at discharge. Data were evaluated using a combination of split plot (level III v I-II = main factor; individual centre = subfactor) and stepwise regression analyses. Results were considered significant at p < 0.05. Resulls: A total of 659 (level III, n = 335; level I-II, n = 324) infants were admitted over a 24 month period (January 1998-December 1999). No differences were detected in birth characteristics, CRIB score (a measure of illness in the first 24 hours of life), length of hospital stay, weight gain, weight at discharge, or degree of PGR between infants discharged from level III and level I-II units. Significant variation was noted in length of hospital stay (∼35%; p < 0.001), weight gain (∼33%; p < 0.001), weight at discharge (∼20%; p < 0.001), and degree of PGR (∼200%; p < 0.001) between the level III units. Even greater variability was noted in the duration of hospital stay (∼40%; p < 0.001), weight gain (∼60%; p < 0.001), weight at discharge (∼40%, p < 0.001), and degree of PGR (∼300%, p < 0.001) between the level I-II units. Conclusions: These data stress the variable but universal nature of PGR in preterm infants discharged from level III and I-II neonatal intensive care units and raise important questions about nutritional support of these infants before and after hospital discharge.
Author(s): Cooke RJ, Ainsworth SB, Fenton AC
Publication type: Article
Publication status: Published
Journal: Archives of Disease in Childhood - Fetal and Neonatal Edition
Year: 2004
Volume: 89
Issue: 5
Pages: F428-F430
ISSN (print): 1359-2998
ISSN (electronic): 1468-2052
Publisher: BMJ Publishing Group
URL: http://dx.doi.org/10.1136/adc.2001.004044
DOI: 10.1136/adc.2001.004044
PubMed id: 15321963
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