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Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health

Lookup NU author(s): Dr Kirsten BrandtORCiD

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Abstract

Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats. © 2004 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Brandt K, Christensen LP, Hansen-Moller J, Hansen SL, Haraldsdottir J, Jespersen L, Purup S, Kharazmi A, Barkholt V, Frokiaer H, Kobaek-Larsen M

Publication type: Article

Publication status: Published

Journal: Trends in Food Science and Technology

Year: 2004

Volume: 15

Issue: 7-8

Pages: 384-393

ISSN (print): 0924-2244

ISSN (electronic):

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.tifs.2003.12.003

DOI: 10.1016/j.tifs.2003.12.003

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