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The potential role of genes in nonalcoholic fatty liver disease

Lookup NU author(s): Professor Chris Day

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Abstract

Investigators searching for genetic factors involved in NASH susceptibility using available technology face several potential pitfalls. These can be overcome by appropriate and careful study design, however, and recent advances in understanding of basic disease mechanisms have suggested a range of genes worthy of subjecting to SNP screening strategies and case-control allele association studies. In the future, the selection of candidate genes seems likely to be guided by mRNA and protein expression profiling of serum and liver tissue from patients with different stages of disease, and possibly, by phenotype-driven mouse mutagenesis approaches. Eventually the availability of a comprehensive SNP-based haplotype map of the human genome along with economically viable rapid throughput genotyping technology will enable genome-wide, haplotype-based association studies in NASH. Together, these modern approaches are likely to lead to the identification of many, as yet unknown, or, at best, unsuspected susceptibility genes that will enhance understanding of disease pathogenesis, and accordingly, the ability to design effective therapies.

Publication metadata

Author(s): Day CP

Publication type: Review

Publication status: Published

Journal: Clinics in Liver Disease

Year: 2004

Volume: 8

Issue: 3

Pages: 673-691

ISSN (print): 1089-3261

ISSN (electronic): 1557-8224

URL: http://dx.doi.org/10.1016/j.cld.2004.04.001

DOI: 10.1016/j.cld.2004.04.001

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