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Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma

Lookup NU author(s): Dr Thomas Ressiniotis, Philip Griffiths, Dr Mark Birch, Sharon Foster, Professor Patrick Chinnery


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Purpose: Primary open angle glaucoma (POAG) is a major cause of late onset visual failure of unknown etiology. Recent genetic association studies have implicated the apolipoprotein E (APOE) gene in the pathophysiology of primary open angle glaucoma, but there have been conflicting findings. Methods: To resolve this issue we studied 140 cases and 73 controls that were carefully phenotyped, and used a logistic regression model to simultaneously analyze the effect of apolipoprotein E genotype and functional polymorphisms in the apolipoprotein E gene promoter while controlling for potentially confounding variables. Results: We found no evidence of an association between the apolipoprotein E promoter region polymorphisms and primary open angle glaucoma. Conclusions: Apolipoprotein E promoter polymorphisms are unlikely to have a major impact on the pathophysiology of primary open angle glaucoma. © 2004 Molecular Vision.

Publication metadata

Author(s): Ressiniotis T, Griffiths PG, Birch M, Keers SM, Chinnery PF

Publication type: Article

Publication status: Published

Journal: Molecular Vision

Year: 2004

Volume: 10

Pages: 805-807

ISSN (print): 1090-0535

ISSN (electronic):

Publisher: Molecular Vision

PubMed id: 15525904