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Differences in regulatory properties between human and rat glucokinase regulatory protein

Lookup NU author(s): Katy Brocklehurst, Emerita Professor Loranne Agius

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Abstract

The inhibition of glucokinase by rat and Xenopus GKRPs (glucokinase regulatory protein) is well documented. We report a comparison of the effects of human and rat GKRPs on glucokinase activity. Human GKRP is a more potent inhibitor of glucokinase than rat GKRP in the absence of fructose 6-phosphate or sorbitol 6-phosphate, and has a higher affinity for these ligands. However, human and rat GKRPs have similar affinities for fructose 1-phosphate and chloride. Residues that are not conserved between the rodent and human proteins affect both the affinity for fructose 6-phosphate and sorbitol 6-phosphate and the inhibitory potency of GKRP on glucokinase in the absence of these ligands.

Publication metadata

Author(s): Brocklehurst KJ, Davies RA, Agius L

Publication type: Article

Publication status: Published

Journal: Biochemical Journal

Year: 2004

Volume: 378

Issue: 2

Pages: 693-697

ISSN (print): 0264-6021

ISSN (electronic): 1470-8728

Publisher: Portland Press Ltd

URL: http://dx.doi.org/10.1042/BJ20031414

DOI: 10.1042/BJ20031414

PubMed id: 14627435

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