Publications by Professor Loranne Agius - ePrints

Browsing publications by Professor Loranne Agius.

Newcastle Authors	Title	Year
Dr Brian Ford Dr Shruti Chachra Ahmed Alshawi Professor Fiona Oakley Professor Dina Tiniakos et al.	Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants	2024
Professor Loranne Agius Dr Brian Ford	Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency	2024
Dr Brian Ford Dr Shruti Chachra Katrina Rodgers Tabassum Moonira Dr Ziad Al-Oanzi et al.	The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326	2023
Dr Brian Ford Dr Shruti Chachra Ahmed Alshawi Alfie Brennan Dr Suzannah Harnor et al.	Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge	2020
Tabassum Moonira Dr Shruti Chachra Dr Brian Ford Ahmed Alshawi Dr Catherine Arden et al.	Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation	2020
Dr Alistair Leitch Dr Tarek Mamdouh Abdelghany Dr Alex Charlton Professor Fiona Oakley Dr Lee Borthwick et al.	Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse	2020
Professor Loranne Agius Dr Brian Ford Dr Shruti Chachra	The metformin mechanism on gluconeogenesis and AMPK activation: The metabolite perspective	2020
Professor Loranne Agius Dr Shruti Chachra Dr Brian Ford	The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective	2020
Dr Ziad Al-Oanzi Professor Loranne Agius	Identification of C‑β‑D‑Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies	2019
Ahmed Alshawi Professor Loranne Agius	Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism	2019
Professor Loranne Agius Professor Quentin Anstee	Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants	2018
Professor Loranne Agius Professor Quentin Anstee	Application of long single-stranded DNA donors in genome editing: Generation and validation of mouse mutants	2018
Dr Alistair Leitch Anne Lakey will Hotham Professor Loranne Agius Professor George Kass et al.	The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha	2018
Dr Ziad Al-Oanzi Sofia Fountana Tabassum Moonira Dr Susan Tudhope John Petrie et al.	Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes	2017
Professor Loranne Agius	Dietary carbohydrate and control of hepatic gene expression: mechanistic links from ATP and phosphate ester homeostasis to the carbohydrate-response element-binding protein	2016
Professor Loranne Agius	Hormonal and Metabolite Regulation of Hepatic Glucokinase	2016
Tabassum Moonira Dr Ziad Al-Oanzi Dr Catherine Arden Professor Loranne Agius	Metformin action in hepatocytes is not mimicked by selective activation of AMPactivated protein kinase	2016
Dr Ziad Al-Oanzi Sofia Fountana Professor Loranne Agius	Mechanism of action of metformin in regulating hepatic gene expression	2015
Professor Loranne Agius	Role of glycogen phosphorylase in liver glycogen metabolism	2015
Kirsty Cullen Dr Ziad Al-Oanzi Professor Loranne Agius Dr Catherine Arden	Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein	2014
Professor Loranne Agius	Lessons from glucokinase activators: the problem of declining efficacy	2014
Dr John Petrie Sofia Fountana Professor Loranne Agius	Opposite effects of glucokinase activators and metformin on gene expression in hepatocytes	2014
Professor Loranne Agius	Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-ᴅ-glucopyranosylamines	2014
Dr Phillip Probert Git Chung Dr Simon Cockell Professor Loranne Agius Steven White et al.	Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies	2014
Dr Catherine Arden Kirsty Cullen Dr Ziad Al-Oanzi Professor Loranne Agius	A role for glucagon in the post-translational regulation of hepatic glucokinase activity	2013
Dr John Petrie Dr Ziad Al-Oanzi Dr Catherine Arden Dr Susan Tudhope Professor Jelena Mann et al.	Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter	2013
Professor Loranne Agius	High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload	2013
Dr Gillian Patman Professor Loranne Agius Douglas Hui Dr Despoina Televantou Professor Helen Reeves et al.	Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis	2013
John Petrie Dr Gillian Patman Ishita Sinha Professor Helen Reeves Professor Loranne Agius et al.	The rate of production of uric acid by hepatocytes is a sensitive index of compromised cell ATP homeostasis	2013
Dr Susan Tudhope Dr Fiona Malcomson Dr Catherine Arden Dr Laura Hampson Professor Loranne Agius et al.	A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5	2012
Professor Loranne Agius	Comment on: Stefanovski et al. Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics. Diabetes Care 2012;35: 1015-1020	2012
Dr Catherine Arden Dr Susan Tudhope Dr Ziad Al-Oanzi Kirsty Cullen Professor Loranne Agius et al.	Fructose 2,6-bisphosphate is essential for glucose-regulated genetranscription of glucose-6-phosphatase and other ChREBP target genes inhepatocytes	2012
Dr Gillian Patman Laura Pascoe Dr Luca Miele Douglas Hui Professor Alastair Burt et al.	Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease	2012
Dr Ziad Al-Oanzi Dr John Petrie Dr Susan Tudhope Dr Catherine Arden Professor Loranne Agius et al.	The insulin-independent glucose-induction of the hepatic gluconeogenic enzyme glucose 6-phosphatase involves distinct metabolic pathways and transcription factors	2012
Professor Helen Reeves Professor Loranne Agius	The Kruppel-like factor 6-IVS1-27A (KLF6) polymorphism is associated with more favourable postprandial glucose metabolism in subjects at high risk of type 2 diabetes	2012
Professor Loranne Agius	Compartmentation of glycogen metabolism revealed from 13C isotopologuedistributions	2011
Dr Catherine Arden Dr Susan Tudhope Dr Ziad Al-Oanzi Professor Loranne Agius	Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis	2011
Professor Loranne Agius Dr Catherine Arden	Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells	2011
Dr Gillian Patman Professor Loranne Agius Professor Helen Reeves	Liver-specific deletion of KLF6 uncovers novel transcriptional pathways linked to lipid and glucose homeostasis	2010
Professor Loranne Agius	Physiological Control of Liver Glycogen Metabolism: Lessons from Novel Glycogen Phosphorylase Inhibitors	2010
Professor Loranne Agius	Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks	2009
Dr Catherine Arden Kirsty Cullen Professor Loranne Agius	Visualisation of protein-protein interactions of glucokinase in living cells	2009
Dr Catherine Arden Dr Laura Hampson Professor James Shaw Dr Ali Aldibbiat Dr Graham Holliman et al.	A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells	2008
Professor Loranne Agius	Glucokinase and molecular aspects of liver glycogen metabolism	2008
Mohammed Mukhtar Victoria Payne Dr Catherine Arden Dr Andrew Harbottle Professor Loranne Agius et al.	Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase	2008
Dr Laura Hampson Professor Loranne Agius	Acetylcholine exerts additive and permissive but not synergistic effects with insulin on glycogen synthesis in hepatocytes	2007
Dr Laura Hampson Professor Loranne Agius	Acetylcholine potentiates the glycogenic actions of insulin in isolated hepatocytes	2007
Dr Catherine Arden Dr Alison Trainer Dr Kathleen Scougall Professor James Shaw Professor Loranne Agius et al.	Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic β-cells: Evidence for cellular instability of catalytic activity	2007
Victoria Payne Dr Catherine Arden Professor Loranne Agius	Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats	2007
Dr Laura Hampson Dr Paul Mackin Professor Loranne Agius	Control of glycogen metabolism in hepatocytes by serotonergic mechanisms and counter-regulation of the glycogenic effect by second-generation antipsychotic drugs	2007
Dr Catherine Arden Professor Loranne Agius	Determination of PFK-2/FBPase-2 isoforms and the role of fructose 2,6 bisphosphate in pancreatic islets and beta-cells lines	2007
Professor Loranne Agius	New hepatic targets for glycaemic control in diabetes	2007
Dr Laura Hampson Dr Paul Mackin Professor Loranne Agius	Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs	2007
Dr Catherine Arden Dr Kathleen Scougall Professor James Shaw Professor Loranne Agius	[abstract] Generation of MIN6 stable cell lines expressing GFP-tagged glucokinase for cellular analysis of glucokinase mutants	2006
Dr Laura Hampson Dr Catherine Arden Professor Loranne Agius	Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site	2006
Dr Catherine Arden Professor James Shaw Professor Loranne Agius	Catalytic instability of the glucokinase MODY-2 mutants V62M and G72R in pancreatic beta cells	2006
Dr Catherine Arden Professor Loranne Agius	Glucokinase regulatory protein is associated with mitochondria in hepatocytes	2006
Professor Loranne Agius	Iminosugars as potential inhibitors of glycogenolysis: Structural insights into the molecular basis of glycogen phosphorylase inhibition	2006
Dr Catherine Arden Dr Laura Hampson Dr Susan Aiston Dr Linda Harndahl Professor Loranne Agius et al.	Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats	2006
Dr Linda Harndahl Professor Loranne Agius	The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism	2006
Dr Susan Aiston Dr Laura Hampson Dr Catherine Arden Professor Loranne Agius	The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes	2006
Victoria Payne Dr Catherine Arden Professor Loranne Agius	Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes	2005
Dr Laura Hampson Professor Loranne Agius	Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism	2005
Katy Brocklehurst Professor Loranne Agius	Differences in regulatory properties between human and rat glucokinase regulatory protein	2004
Dr Catherine Arden Dr Andrew Harbottle Professor Loranne Agius	Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation	2004
Dr Susan Aiston Mohammed Mukhtar Professor Loranne Agius	Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose	2004
Katy Brocklehurst Victoria Payne Dr Susan Aiston Professor Loranne Agius	Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators	2004
Andrew Green Dr Susan Aiston Professor Loranne Agius	The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation	2004
Dr Susan Aiston Professor Loranne Agius	Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase	2003
Dr Susan Aiston Professor Loranne Agius	Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis	2003
Dr Anna Tavridou Professor Loranne Agius	Phosphorylase regulates the association of glycogen synthase with a proteoglycogen substrate in hepatocytes	2003
Theodoros Latsis Professor Loranne Agius	Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes	2002
Professor Loranne Agius	Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?	2002
Dr Susan Aiston Dr Laura Hampson Professor Loranne Agius	Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: Evidence from metabolic control analysis	2001
Professor Loranne Agius	Occurrence of paradoxical or sustained control by an enzyme when overexpressed: Necessary conditions and experimental evidence with regard to hepatic glucokinase	2001
Dr Susan Aiston Professor Loranne Agius	Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: The role of increased phosphorylase activity	2000
Professor Loranne Agius Dr Mark Stubbs	Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: Evidence for two glucose binding sites	2000
Dr Mark Stubbs Dr Susan Aiston Professor Loranne Agius	Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells	2000
Professor Loranne Agius Dr Susan Aiston	The control strength of glucokinase in hepatocytes: A predictor of metabolic defects in maturity onset diabetes of the young, type 2	2000
Mohammed Mukhtar Professor Loranne Agius	The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte	2000
Professor Loranne Agius	Use of α-toxin from Staphylococcus aureus to test for channelling of intermediates of glycolysis between glucokinase and aldolase in hepatocytes	2000
Mohammed Mukhtar Dr Mark Stubbs Professor Loranne Agius	Evidence for glucose and sorbitol-induced nuclear export of glucokinase regulatory protein in hepatocytes	1999
Professor Loranne Agius	Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase	1999
Professor Loranne Agius Emeritus Professor Steve Yeaman Professor Chris Day	Inhibition of rat hepatocyte proliferation by transforming growth factor beta and glucagon is associated with inhibition of ERK2 and p70 S6 kinase	1999
Dr Susan Aiston Professor Loranne Agius	Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin	1999
Professor Loranne Agius	The role of glucokinase translocation in the hepatocyte in the control of glucose metabolism	1999
Professor Loranne Agius	The hepatocyte cytoskeleton. Biochemical, physiological, and pathological aspects	1996