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Browsing publications by Emerita Professor Loranne Agius

Newcastle AuthorsTitleYearFull text
Emerita Professor Loranne Agius
Glucokinase Activators. A Humbling Lesson in Drug Development2025
Dr Brian Ford
Dr Shruti Chachra
Ahmed Alshawi
Professor Fiona Oakley
Professor Dina Tiniakos
et al.		Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants2024
Emerita Professor Loranne Agius
Dr Brian Ford
Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency2024
Dr Brian Ford
Dr Shruti Chachra
Katrina Rodgers
Tabassum Moonira
Dr Ziad Al-Oanzi
et al.		The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs12603262023
Dr Brian Ford
Dr Shruti Chachra
Ahmed Alshawi
Alfie Brennan
Dr Suzannah Harnor
et al.		Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge2020
Tabassum Moonira
Dr Shruti Chachra
Dr Brian Ford
Ahmed Alshawi
Dr Catherine Arden
et al.		Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation2020
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Professor Fiona Oakley
Dr Lee Borthwick
et al.		Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse2020
Emerita Professor Loranne Agius
Dr Brian Ford
Dr Shruti Chachra
The metformin mechanism on gluconeogenesis and AMPK activation: The metabolite perspective2020
Emerita Professor Loranne Agius
Dr Shruti Chachra
Dr Brian Ford
The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective2020
Dr Ziad Al-Oanzi
Emerita Professor Loranne Agius
Identification of C‑β‑D‑Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies2019
Ahmed Alshawi
Emerita Professor Loranne Agius
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism2019
Emerita Professor Loranne Agius
Professor Quentin Anstee
Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants2018
Emerita Professor Loranne Agius
Professor Quentin Anstee
Application of long single-stranded DNA donors in genome editing: Generation and validation of mouse mutants2018
Dr Alistair Leitch
Anne Lakey
will Hotham
Emerita Professor Loranne Agius
Professor George Kass
et al.		The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha2018
Dr Ziad Al-Oanzi
Sofia Fountana
Tabassum Moonira
Dr Susan Tudhope
John Petrie
et al.		Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes2017
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