Browse by author
Lookup NU author(s): Dr Yoshiharu Sakamoto,
Dr Roger Searle,
Dr Judith Bulmer,
Professor Steve Robson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Our aim was to determine the amount and source of interleukin (IL)-8 and to study IL-8 receptor expression in the human cervix during pregnancy and after labour. Cervical biopsies were obtained from six non-pregnant women, eight women undergoing pregnancy termination, 17 women undergoing elective caesarean section and 11 women after vaginal delivery. IL-8 levels were compared in women with and without a ripe cervix, as determined by cervical Bishop score and cervicovaginal fetal fibronectin levels. Levels of IL-8 and IL-1β, a regulator of IL-8 expression, were determined by enzyme-linked immunosorbent assay (ELISA). IL-8, IL-1β and IL-8 receptor proteins were localized by immunohistochemistry. Compared with late pregnancy, IL-8 levels increased after labour and vaginal delivery (P < 0.01) but there was no correlation with cervical ripening. IL-8 was localized to stromal cells, macrophages and granulocytes. There were no significant differences in IL-1β levels between groups. IL-8 receptors were expressed primarily on granulocytes and macrophages after vaginal delivery. We conclude that IL-8 is involved in cervical dilatation but not in cervical ripening.
Author(s): Sakamoto Y, Moran P, Searle RF, Bulmer JN, Robson SC
Publication type: Article
Publication status: Published
Journal: Clinical and Experimental Immunology
ISSN (print): 0009-9104
ISSN (electronic): 1365-2249
PubMed id: 15373918
Altmetrics provided by Altmetric