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Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes

Lookup NU author(s): Professor Patrick Chinnery, Dr Hannah Elliott, Dr Sheila Patel, Claire Lambert, Dr Steve Durham, Anne Hattersley, Professor Mark Walker


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Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1·16, 95% CI 0·94-1·44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.

Publication metadata

Author(s): Chinnery PF, Elliott HR, Patel S, Lambert C, Keers SM, Durham SE, McCarthy MI, Hitman GA, Hattersley AT, Walker M

Publication type: Article

Publication status: Published

Journal: Lancet

Year: 2005

Volume: 366

Issue: 9497

Pages: 1650-1651

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: Lancet Publishing Group


DOI: 10.1016/S0140-6736(05)67492-2

PubMed id: 16271646


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