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Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon

Lookup NU author(s): Vasileios Pagmantidis, Dr Stephane Villette, Professor John Hesketh


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Selenium (Se)-containing proteins have important roles in protecting cells from oxidative damage. This work investigated the effects of Se-depletion on the expression of the genes encoding selenoproteins in colonic mucosa from rats fed diets of different Se content and in human intestinal Caco-2 cells grown in Se-adequate or Se-depleted culture medium. Se-depletion produced statistically significant (P < 0.05) falls in glutathione peroxidase (GPX) 1 mRNA (60-83%) and selenoprotein W mRNA (73%) levels, a small but significant fall in GPX4 mRNA (17-25%) but no significant change in GPX2. The data show that SelW expression in the colon is highly sensitive to Se-depletion. © 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Pagmantidis V, Bermano G, Villette S, Broom I, Arthur J, Hesketh J

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2005

Volume: 579

Issue: 3

Pages: 792-796

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV


DOI: 10.1016/j.febslet.2004.12.042

PubMed id: 15670848


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