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Polarised distribution of the RNA-binding protein Staufen in differentiated intestinal epithelial cells

Lookup NU author(s): Dr Hannah Gautrey, Dr Judith Hall, Professor John Hesketh

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Abstract

mRNA localisation, as a mechanism for directing localised protein synthesis, plays a vital role in the functioning of certain cells, such as neurons and oocytes. Potentially this mechanism may also occur in polarised intestinal epithelial cells. Here we show that Staufen155, a protein involved in mRNA localisation and transport, is asymmetrically distributed in differentiated Caco-2 intestinal epithelial cells and partly co-localised with calnexin, a marker of the endoplasmic reticulum. The localisation to the apical region of the cell indicates that Staufen may be involved in localisation of transcripts to this domain. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Gautrey H, McConnell J, Hall J, Hesketh J

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2005

Volume: 579

Issue: 10

Pages: 2226-2230

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.febslet.2005.02.074

DOI: 10.1016/j.febslet.2005.02.074

PubMed id: 15811346


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