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Lookup NU author(s): Professor Patrick Chinnery,
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While skeletal muscles generally perform specific limited roles, extraocular muscles (EOMs) have to be responsive over a wider dynamic range. As a result, EOMs have fundamentally distinct structural, functional, biochemical and immunological properties compared to other skeletal muscles. While these properties enable high fatigue resistance and the rapid and precise control of extraocular motility, they might also explain why EOMs are selectively involved in certain disorders, such as chronic progressive external ophthalmoplegia (CPEO), myasthenia gravis and Graves' ophthalmopathy. This review first gives an overview of the novel myofibre classification in EOMs and then focuses on those properties that might explain why ophthalmoplegia should be so prominent in these disorders. © 2004 Elsevier B.V. All rights reserved.
Author(s): Yu Wai Man CY, Chinnery PF, Griffiths PG
Publication type: Review
Publication status: Published
Journal: Neuromuscular Disorders
Print publication date: 01/01/2005
ISSN (print): 0960-8966
ISSN (electronic): 1873-2364
PubMed id: 15639116