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Lookup NU author(s): Petra Stojkovic,
Professor Majlinda LakoORCiD,
Professor Lyle Armstrong,
Professor Miodrag Stojkovic
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Human embryonic stem cells (hESC) are pluripotent cells derived from early human embryos with the potential to maintain an undifferentiated state indefinitely. hESC express typical cell-surface and intracellular markers, possess high levels of telomerase activity, show normal karyotype and have the potential to differentiate into numerous cell types under in vitro and in vivo conditions. Therefore, hESC hold great promise for the development of cell transplantation therapies for the treatment of various human diseases. On the other hand, numerous factors limite medical application of hESC cells: hESC exhibit high genomic instability after long-term growth and this growth requires presence of ingredients of animal origin. However, in this study we demonstrate that hESC grown for more than 70 passages maintain pluripotency, their genomic stability and ability to differentiate into different cell types under in vitro conditions.
Author(s): Stojkovic P, Lako M, Armstrong L, Stojkovic M
Publication type: Article
Publication status: Published
ISSN (print): 1450-7994
ISSN (electronic): 1820-1776
Publisher: Univerzitet u Kragujevcu