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Human embryonic stem cells express markers of pluripotency and differentiate under long-term in vitro growth conditions

Lookup NU author(s): Petra Stojkovic, Professor Majlinda LakoORCiD, Professor Lyle Armstrong, Professor Miodrag Stojkovic


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Human embryonic stem cells (hESC) are pluripotent cells derived from early human embryos with the potential to maintain an undifferentiated state indefinitely. hESC express typical cell-surface and intracellular markers, possess high levels of telomerase activity, show normal karyotype and have the potential to differentiate into numerous cell types under in vitro and in vivo conditions. Therefore, hESC hold great promise for the development of cell transplantation therapies for the treatment of various human diseases. On the other hand, numerous factors limite medical application of hESC cells: hESC exhibit high genomic instability after long-term growth and this growth requires presence of ingredients of animal origin. However, in this study we demonstrate that hESC grown for more than 70 passages maintain pluripotency, their genomic stability and ability to differentiate into different cell types under in vitro conditions.

Publication metadata

Author(s): Stojkovic P, Lako M, Armstrong L, Stojkovic M

Publication type: Article

Publication status: Published

Journal: Medicus

Year: 2005

Volume: 6

Issue: 1

Pages: 6-10

ISSN (print): 1450-7994

ISSN (electronic): 1820-1776

Publisher: Univerzitet u Kragujevcu