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Synaptic pathways in neural microcircuits

Lookup NU author(s): Dr Fiona LeBeau


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The functions performed by different neural microcircuits depend on the anatomical and physiological properties of the various synaptic pathways connecting neurons. Neural microcircuits across various species and brain regions are similar in terms of their repertoire of neurotransmitters, their synaptic kinetics, their short-term and long-term plasticity, and the target-specificity of their synaptic connections. However, microcircuits can be fundamentally different in terms of the precise recurrent design used to achieve a specific functionality. In this review, which is part of the TINS Microcircuits Special Feature, we compare the connectivity designs in spinal, hippocampal, neocortical and cerebellar microcircuits, and discuss the different computational challenges that each microcircuit faces. © 2005 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Silberberg G, Grillner S, Le Beau FEN, Maex R, Markram H

Publication type: Review

Publication status: Published

Journal: Trends in Neurosciences

Year: 2005

Volume: 28

Issue: 10

Pages: 541-551

Print publication date: 01/10/2005

ISSN (print): 0166-2236

ISSN (electronic): 1878-108X


DOI: 10.1016/j.tins.2005.08.004

PubMed id: 16122815