Browse by author
Lookup NU author(s): Professor Christopher WardORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Purpose of the review: We have attempted to bring together recent findings, mainly from airway endobronchial biopsies, on the structural changes that constitute 'remodelling' in airway disease, with a particular focus on asthma. We have tried to put this into the context of classic studies on the asthma pathological phenotype. Having described these basic changes, we have then given an update on recent studies investigating the effects of corticosteroid medication on the different manifestations of remodelled airways. Recent findings: The effects of corticosteroid on airway remodelling seem to vary a great deal; some aspects are steroid responsive while others are not, or less so. It is likely that different manifestations of remodelling require different doses and timescales for treatment to be effective. Summary: Further longitudinal interventional studies are required, with multiple airway sampling times, to fully elucidate the full potential for corticosteroids to benefit remodelling of the airways in chronic inflammatory diseases. There needs to be more attention to pathophysiological and clinical correlations in such studies. It is likely that even when used optimally corticosteroids will have limited efficacy overall in this aspect of asthma pathogenesis. The search is on for newer and better treatments.
Author(s): Ward C, Walters H
Publication type: Article
Publication status: Published
Journal: Current Opinion in Allergy and Clinical Immunology
Print publication date: 01/02/2005
ISSN (print): 1528-4050
ISSN (electronic): 1473-6322
Publisher: Lippincott Williams & Wilkins
PubMed id: 15643343
Altmetrics provided by Altmetric