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Ocular motility findings in chronic progressive external ophthalmoplegia

Lookup NU author(s): Dr Terence Smith, Dr Andrew Schaefer, Emeritus Professor Doug Turnbull, Philip Griffiths


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Aims: To characterise the ocular motility features of chronic progressive external ophthalmoplegia by quantitative and semiquantitative means. To assess the prevalence of diplopia and the binocular adaptations to nonaligned visual axes. Method: We studied 25 patients with chronic progressive external ophthalmoplegia. In each case muscle biopsies were consistent with mitochondrial myopathy. All patients underwent cover test in the primary position, assessment of binocular status, and measurement of uniocular fields of fixation using the Goldmann perimeter. Results: A total of 23 (92%) patients had an exo-deviation, with six (26%) of those having an associated vertical deviation: 12 patients were binocular. Of the 13 patients with a manifest deviation seven had diplopia and six had suppression. Of all paired extra-ocular muscles (EOM), 68% had symmetry of movement within 5° of each other. Conclusion: Almost all patients had an exodeviation. Diplopia was more common than expected. The majority of patients had symmetry of EOM limitation. © 2005 Nature Publishing Group All rights reserved.

Publication metadata

Author(s): Richardson C, Smith T, Schaefer A, Turnbull D, Griffiths P

Publication type: Article

Publication status: Published

Journal: Eye

Year: 2005

Volume: 19

Issue: 3

Pages: 258-263

ISSN (print): 0950-222X

ISSN (electronic): 1476-5454

Publisher: Nature Publishing Group


DOI: 10.1038/sj.eye.6701488

PubMed id: 15272295


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