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Galactomannan hydrolysis and mannose metabolism in Cellvibrio mixtus

Lookup NU author(s): Carl Morland, Dr Louise Tailford, Emeritus Professor Harry Gilbert


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Galactomannan hydrolysis results from the concerted action of microbial endomannanases, manosidases and α-galactosidases and is a mechanism of intrinsic biological importance. Here we report the identification of a gene cluster in the aerobic soil bacterium Cellvibrio mixtus encoding enzymes involved in the degradation of this polymeric substrate. The family 27 α-galactosidase, termed CmAga27A, preferentially hydrolyse galactose containing polysaccharides. In addition, we have characterized an enzyme with epimerase activity, which might be responsible for the conversion of mannose into glucose. The role of the identified enzymes in the hydrolysis of galactomannan by aerobic bacteria is discussed. © 2006 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

Publication metadata

Author(s): Centeno MSJ, Guerreiro CIPD, Dias FMV, Morland C, Tailford LE, Goyal A, Prates JAM, Ferreira LMA, Caldeira RMH, Mongodin EF, Nelson KE, Gilbert HJ, Fontes CMGA

Publication type: Article

Publication status: Published

Journal: FEMS Microbiology Letters

Year: 2006

Volume: 261

Issue: 1

Pages: 123-132

ISSN (print): 0378-1097

ISSN (electronic): 1574-6968

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1574-6968.2006.00342.x

PubMed id: 16842369


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