Toggle Main Menu Toggle Search

Open Access padlockePrints

Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection

Lookup NU author(s): Sophie Noblett, Dr Christopher Snowden, Dr Brian Shenton, Alan Horgan


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background: Protocolized fluid administration using oesophageal Doppler monitoring may improve the postoperative outcome in patients undergoing surgery. Methods: A total of 108 patients undergoing elective colorectal resection were recruited into a double-blind prospective randomized controlled trial. An oesophageal Doppler probe was placed in all patients. The control group received perioperative fluid at the discretion of the anaesthetist, whereas the intervention group received additional colloid boluses based on Doppler assessment. Primary outcome was length of postoperative hospital stay. Secondary outcomes were morbidity, return of gastrointestinal function and cytokine markers of the systemic inflammatory response. Standard preoperative and postoperative management was used in all patients. Results: Demographic and surgical details were similar in the two groups. Aortic flow time, stroke volume, cardiac output and cardiac index during the intraoperative period were higher in the intervention group (P < 0.050). The intervention group had a reduced postoperative hospital stay (7 versus 9 days in the control group; P = 0.005), fewer intermediate or major postoperative complications (2 versus 15 per cent; P = 0.043) and tolerated diet earlier (2 versus 4 days; P = 0.029). There was a reduced rise in perioperative level of the cytokine interleukin 6 in the intervention group (P = 0.039). Conclusion: A protocol-based fluid optimization programme using intraoperative oesophageal Doppler monitoring leads to a shorter hospital stay and decreased morbidity in patients undergoing elective colorectal resection. Copyright © 2006 British Journal of Surgery Society Ltd.

Publication metadata

Author(s): Noblett, S.E., Snowden, C.P., Shenton, B.K., Horgan, A.

Publication type: Article

Publication status: Published

Journal: British Journal of Surgery

Year: 2006

Volume: 93

Issue: 9

Pages: 1069-1076

Print publication date: 01/09/2006

ISSN (print): 0007-1323

ISSN (electronic): 1365-2168


DOI: 10.1002/bjs.5454

PubMed id: 16888706


Altmetrics provided by Altmetric